UN Urges More Funds for Early HIV Treatment

The UN Programme on HIV/Aids (UNAids) has called for increased funding for the early treatment of people with HIV.

The head of the agency, Michael Sidibe, said a new study showed it could reduce the risk of HIV transmission by 96%.

He said the challenge was to expand access to drugs, and deal with social factors which stigmatise the disease.

On Thursday, a UN report said there had been a nearly 25% decline in new HIV infections and a reduction in Aids-related deaths during the past decade.

It was published ahead of the 30th anniversary on Sunday of the first official report on Aids by the US Centers for Disease Control and Prevention.

The General Assembly is to meet at UN headquarters to discuss the epidemic next week, with 20 world leaders and more than 100 ministers expected to attend.

An estimated 34 million people were living with HIV at the end of 2010 and nearly 30 million have died from Aids-related causes since 1981, the report said.

‘Shunned disease’

In the report published ahead of the anniversary, UNAids said the global rate of new HIV infections had declined by nearly 25% between 2001 and 2009.

In India, the rate of new HIV infections fell by more than 50% and in South Africa by more than 35%; both countries have the largest number of people living with HIV on their continents.

The report found that in the third decade of the epidemic, people were starting to adopt safer sexual behaviour, reflecting the impact of HIV prevention and awareness efforts. But there were still important gaps, it warned, with young men more likely to be informed about HIV prevention than young women.

There has also been significant progress in preventing new HIV infections among children as increasing numbers of mothers living with HIV have gained access to antiretroviral prophylaxis during pregnancy, delivery and breastfeeding.

About 6.6 million people in low- and middle-income countries were receiving antiretroviral drugs at the end of 2010, a nearly 22-fold increase since 2001.

“Thirty years ago this mystery disease was called a gay plague – it was a shunned disease, people were scared about each other,” Mr Sidibe said. “Now it’s a completely different world – we’ve been breaking the conspiracy of silence.”

However, the report found that at the end of last year nearly nine million people who needed treatment were not getting it, and that treatment access for children was lower than for adults.

And while the rate of new HIV infections has declined globally, the total number of HIV infections remains high, at about 7,000 per day.

The report also noted that there had been an increase in the rate of new HIV infections in Eastern Europe and in the Middle East and North Africa, and that HIV was the leading cause of death among women of reproductive age.

‘Game-changer’

UNAids also said that while funding for HIV treatments in low- and middle-income countries had risen 10-fold between 2001 and 2009, international resources had declined in 2010. Many states remain dependant on external financing.

“I am worried that international investments are falling at a time when the Aids response is delivering results for people,” Mr Sidibe said. “If we do not invest now, we will have to pay several times more in the future.”

He stressed the importance of a recent trial, which found that if a person living with HIV adhered to an effective antiretroviral regimen, the risk of transmitting the virus to their uninfected sexual partner could be reduced by 96%.

“Access to treatment will transform the Aids response in the next decade. We must invest in accelerating access and finding new treatment options.

“Antiretroviral therapy is a bigger game-changer than ever before – it not only stops people from dying, but also prevents transmission of HIV to women, men and children,” he added.

Mr Sidibe said the challenge was to expand access to drugs, and deal with social factors that in some countries continue to stigmatise the disease and make women particularly vulnerable.

To do this, UNAids believes an investment of at least $22bn is needed by 2015, $6bn more than is available today. It estimates such funds would stop 12m new HIV infections and 7.4m Aids-related deaths by 2020.

Poverty Link to Starting Periods Younger

Girls from poorer backgrounds are more likely to start their periods at a younger age, thereby increasing their risk of breast cancer, a UK study says.

It found girls in lower socio-economic groups with typically poorer diets began at 12.1 years on average compared to 12.5 years for wealthier girls.

Their breast cancer risk was greater as they produced the hormone oestrogen longer, the study of 90,000 women says.

It was published in the journal Paediatric and Perinatal Epidemiology.

The research data being gathered from this group of women over 40 years is also helping to find the causes and risk factors associated with breast cancer.

The study is a partnership between Breakthrough Breast Cancer and the Institute of Cancer Research.

This research found that there was little change in the age of menarche (when a girl’s periods begin) for 40 years until the late 1980s.

Then the age dropped from 12.6 years to about 12.3 years, with the drop steepest in poorer areas.

Study author Danielle Morris, from The Institute of Cancer Research in Surrey, said the results suggested that girls, particularly from poorer backgrounds, are starting their periods younger.

“While we don’t know all the reasons behind this, changes in diet may have played a part.

“This decrease is important because the age at which a girl starts her periods can influence her chances of developing breast cancer later in life.”

Oestrogen effect

Dr Tabitha Randall, consultant paediatrician at Nottingham Children’s Hospital, said this was due to exposure to the hormone oestrogen.

“Girls who start their periods earlier are producing oestrogen for longer periods of time, although those who start their periods early normally finish early, but then they may start taking hormone replacement therapy.”

Previous research has shown that the female hormone oestrogen is linked to the growth of breast tumours.

Levels of oestrogen in the body are also influenced by diet and, therefore, body weight.

“Diet is important because fatty tissue turns male hormones into oestrogen,” said Dr Randall.

Previously, girls from higher socio-economic groups tended to start their periods younger because their affluence led to greater food intake and heavier body weight.

But researchers say the trend appears to have reversed.

Girls of lower socio-economic status are now starting their periods at a younger age (12.1 years) than girls from wealthier backgrounds (12.5 years) because they are the ones who tend to have poorer diets and are more likely to be overweight.

The age at which girls start their periods can be added to the list of risk factors for breast cancers, which are known to be a woman’s age, alcohol intake, weight and use of hormone replacement therapy and the contraceptive pill.

A family history of breast cancer may also increase the risk of developing the disease.

Professor Anthony Swerdlow, co-leader of the Breakthrough Generations Study, says that the incidence of breast cancer has risen progressively over a long time in the UK.

“We think these changes have come about through a combination of factors each of which individually makes a small difference.

“Understanding how these factors influence a woman’s risk of developing breast cancer should allow us to develop strategies for preventing the disease in the future.”

Newly Identified Chemicals Fool Mosquitoes

Researchers have identified a low-cost chemical that interferes with a mosquito’s ability to detect humans, a study which offers a striking breakthrough in the battle against malaria.

Mosquitoes have carbon dioxide sensors with which they are able to smell the presence of humans in their neighborhood. The newly identified chemicals consist of odor molecules that disrupt these carbon-dioxide sensors located in small, antennae-like appendages close to the mosquito’s mouth, thereby disrupting the mechanism that alert mosquitoes to exhaled human breath. The study is presented in the journal Nature.

It is hoped that the findings could help develop the next generation of mosquito repellents, which could work by confusing the insects.

DEET are the gold standard insect repellants but they are costly and requires repeat applications and therefore beyond the means of many in the developing countries. This discovery could prove invaluable to poor tropical countries by providing an alternative to DEET.

According to the World Health Organization, malaria kills between 800,000 to 1 million people each year, most of who are in Sub-Saharan African. Children and pregnant mothers are the most vulnerable.

UNICEF Urges Greater Attention to Child Rights Violations in Somalia

2 June 2011 –The United Nations Children’s Fund (UNICEF) has draw attention to what it describes as grave violations of children’s rights that are taking place every day in Somalia, which has been wracked by factional warfare since the collapse of the government 20 years ago.

“Children in central-south Somalia face never-ending (unremitting) suffering in what is arguably one of the most extreme, indiscriminate and complex conflicts in today’s world,” the agency stated in a news release issued yesterday.

“Somali children are the most affected by the unrelenting violence in which they risk being killed, maimed or injured when caught in crossfire or as a result of being unlawfully recruited and used on the front lines by all parties to the conflict,” it added.

On Tuesday, the World Health Organization (WHO) reported that violence in Somalia’s capital, Mogadishu, has driven the number of child casualties to a new high, and that the main causes of children’s deaths were burns, chest injuries and internal haemorrhage resulting from blasts, shrapnel and bullets.

UNICEF said that reports by WHO of a 46 per cent increase in weapon-related injuries to children under the age of five in Mogadishu last month underscore the vulnerability of Somali children in the ongoing conflict.

The agency drew attention to the “detrimental and disproportionate” impact the conflict has on children’s physical and mental well-being. Ongoing violence also exposes them to displacement and food insecurity and leaves them without health care, education and protection from abuse.

“Not only is this a tragic humanitarian disaster in the present, it also represents a critical challenge to peace and stability in Somalia in the future,” warned UNICEF.

Somalia has had no fully functioning national government and has been wracked by factional warfare since the collapse in 1991 of the administration led by the late Muhammad Siad Barre.

An estimated 2.4 million people – or about a third of the country’s 7.2 million people – are in need of relief aid as a result of drought and two decades of conflict, most recently between Somalia’s Transitional Federal Government (TFG) and Al-Shabaab Islamic militants.

Gates Foundation Commits $1.7 Billion For Farming In Africa

SEATTLE — The world’s largest charitable foundation announced five years ago it would spend millions of dollars to fight poverty and hunger in Africa, largely by investing in agriculture. To date, the Bill & Melinda Gates Foundation has committed $1.7 billion, but its leaders say it could take 20 years to see the results of that work.

The foundation has focused on ways to bring to Africa the green revolution that swept Latin America and Asia in the mid-1900s, boosting productivity in those regions. Its hope has been that helping small farmers grow more would allow them to sell their surplus, boosting their income and putting more food in hungry mouths. More than 70 percent of the world’s poor depend on agriculture for both their food and income.

Some people have been helped, and the foundation expects more will be in years to come, but agricultural development happens slowly, said Roy Steiner, the foundation’s deputy director of global development.

As an example, he said some Kenyan farmers will receive seeds for drought-tolerant maize this year. They’ll try them out, see the results and decide whether to adopt them more enthusiastically next year. A year after that, increased production could give them more money to buy food for their families or fertilizer to improve their other crops.

“It takes years and years to shift the system,” Steiner said.

A more immediate impact might be made by buying and giving away food, and the Gates Foundation has done this indirectly with grants to groups such as Oxfam and CARE. But Steiner said the foundation doesn’t see this as a long-term solution.

“Giving food to people is certainly necessary when there’s a crisis,” he said. “But these people don’t want to be depending on outside charity. And, frankly, who is going to pay for all of that food being given?”

The foundation, he said, aims to prevent crises by strengthening agriculture systems.

It’s an approach anti-hunger organizations such as CARE and the United Nation’s World Food Programme also are taking. One-fifth or less of CARE’s budget now goes to the kind of direct food aid the nonprofit was created to provide 65 years ago. The rest is focused on agriculture development work similar to what the Gates Foundation is doing.

“This move from more of a charity approach to more of a capacity building and empowerment approach is something most of the major relief and development organizations have gone through,” said Kevin Henry, who directs CARE’s work in agriculture, economic development and climate change.

The World Bank estimates 338 million people live on less a dollar a day in sub-Saharan Africa. The U.S. government spends about $1.7 billion on food aid each year and about $1 billion a year on its Feed the Future Program, which focuses on reducing poverty and hunger through agriculture development.

Gates Foundation believes it can move more than 150 million in Africa out of extreme poverty by 2025 by improving agriculture. To that end, it has invested millions in seed research, buying and distributing fertilizer, improving farmers’ education and access to markets and political advocacy to get governments to spend more money on agriculture and to improve policies ranging from trade to land ownership.

Much of the work has been done through the Alliance for a Green Revolution in Africa, which is run by Africans with heavy support from the foundation. AGRA has used Gates money to support plant breeding programs at nine African universities, help seed companies increase their production, set up soil mapping programs and provide credit to help seed, fertilizer and equipment suppliers expand, among other things.

It has drawn attention from a Seattle nonprofit called AGRA Watch, whose members say they are concerned about the foundation’s interest in genetically modified seeds and its relationship with African farmers. Co-chair Janae Choquette claims the foundation hasn’t talked to enough farmers to find out what kind of help they want.

“Their analysis of solutions is not coming from these communities,” Choquette said. “We want to support of the self-determination of farmers in deciding their own path forward.”

Steiner disputed Choquette’s claim, saying the foundation gets direction for all its work from farmers. But he also said one of its biggest challenges has been a lack of education among farmers.

“We want to make sure that we are really making things better over the long term, not making them worse,” he said.

The foundation says very little of its work involves genetically modified seeds.

Another big chunk of Gates Foundation money, $66 million, has been promised to the World Food Programme to help improve African farmers’ access to markets. The idea is the World Food Program saves money by buying locally, while its purchases put money in farmers’ pockets. Thus far, the program has spent about $30 million with small farmers and small- and medium-sized traders through its Purchase for Progress program.

The head of the foundation’s agriculture department, Sam Dryden, also is pushing it to help increase African farmers’ opportunities to sell their products beyond their own communities. The foundation has invested many millions in helping cocoa, cashew and coffee farmers reach the quality and quantities they need to sell to overseas markets.

A spokesman for Kraft Foods Inc. says that effort has resulted in his company buying some cashews directly from Africa, because the nuts can now be processed there instead of having to be shipped to Asia or elsewhere for processing.

Steve Yucknut, Kraft’s global vice president for sustainability, said the company hasn’t changed the overall amount of cashews it buys, but with his company and the Gates Foundation setting up processing plants in Africa, more of the profit from growing cashews stays in countries there.

What the Successful Have in Common: Passion

Earlier in the Series

Passion is defined as an intense emotion that compels feeling, enthusiasm, or desire for something. My own definition for the purpose of this chapter is the ‘type of feeling you feel about something that makes you feel like you’re really feeling some feeling’.

Passion is the single most important quality shared by all successful people in life or if you like, people who are making real significant impact in some areas in life. Everybody can be okay in something; we can all be average in one thing or the other, but crossing the line of just average to genius doesn’t just take everybody anyhow, it takes individuals with this intense feeling about what they set themselves to do.

My big brother won National Best Teacher Award in 2010. When my sister called to inform me, I wasn’t shocked at all because when I dug deep into his award and considered the way he handles his profession, I could see it happening several years back. His passion for teaching is intense.

With a degree in accounting and commerce, he could strive to secure a high-paying job with a financial institution but he rather chose to teach in elementary school. Surely, that is not what I would choose. To him, there’s not a single day he regrets what he does. He’s not the type of teacher who pupils sleep in class because of the level of enthusiasm with which he executes his duty. Some may envy the physical award that was given him, but I know that what he cherishes most is the pride of living as a National Best Teacher for the rest of this life. That is passion.

If you’re passionate about what you do, it should show in every aspect of your life, not life at the Continue reading “What the Successful Have in Common: Passion”

Mosquitoes are Suckered in New Malaria Research

(AFP) –

PARIS — In the biggest lab breakthrough against malaria in years, scientists on Wednesday said they had identified odour molecules that baffle blood-thirsty mosquitoes.

The molecules disrupt carbon-dioxide sensors that alert mosquitoes to exhaled breath, which signals the presence of a human nearby, the team reported.

The work could lead to revolutionary but low-cost chemicals to confuse, deter or trap mosquitoes, it said.

They could be invaluable in poor tropical countries, providing an alternative to DEET, a skin repellent that is expensive, needs repeat applications and is showing worrying signs of resistance.

“These chemicals offer powerful advantages as potential tools for reducing mosquito-human contact and can lead to the development of new generations of insect repellents and lures,” said Anandasankar Ray, an assistant professor of entomology at the University of California at Riverside, who led the study.

Traps for mosquitoes already exist, in the form of dry ice, gas cylinders of carbon dioxide or propane combustion.

But these gadgets are too bulky and far too expensive to be used for mosquito control, especially in poor settings.

Future mosquito traps, Ray predicted, could be “highly portable, convenient and easily replenishable.”

Malaria claimed 781,000 lives in 2009, according to the UN’s World Health Organisation (WHO), which is heading efforts to distribute insecticide-treated mosquito nets and to spray reproduction sites.

About 90 percent of malaria deaths each year occur in Africa and 92 percent of those are children aged under five.

Other mosquito-borne diseases are dengue, which sickens around 50 million people each year, yellow fever, filariasis and West Nile virus.

Building on research on fruitflies, a common laboratory tool, Ray’s team looked at three of mosquito species whose females are disease vectors: Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus.

The odour molecules that they identified disrupt receptor cells for carbon dioxide located in tiny, antennae-like appendages close to the mosquito’s mouth.

These receptors are activated by a whiff of carbon dioxide, triggering a signal in the brain that prompts the insect to fly upwind, following the puffs of CO2 until they reach its source. Mosquito also use heat sensors and sight to home in on their meal.

The findings have been tested in a small-scale experiment in Kenya, using huts where alluring plumes of CO2 were released to attract mosquitoes and odour molecules were released to bamboozle them.

Mark Stopfer, a specialist at the US National Institutes of Health (NIH), said the results opened up “a promising line of defence.”

He added some words of caution, saying that mosquitoes were attracted to other odours in human sweat and skin. In addition, the chemicals that have been tested on insects so far have not yet been tested for safety on humans, he noted.

Confusing Mosquitoes to Fight Deadly Disease

This image, put together by a UC Riverside researcher, shows the head and olfactory organs of a female mosquito (in foreground) and a fruitfly (background). The red lines are sample electrical recordings from a CO2-sensitive neuron. The red and black molecules show the chemical structures of compounds the research team tested. (Stephanie Turner)

As summer begins, thoughts often turn to hot dogs, hamburgers, watermelon … and mosquitoes.

For most barbecuers, the bugs are little more than a pesky annoyance.  But for millions around the world every year, mosquitoes carrying diseases such as malaria, dengue fever and West Nile virus prove deadly.  Mosquito nets and repellants help fight bites, but public health officials still seek cheaper and more effective ways to fight mosquito-borne disease.

Enter researchers at UC Riverside, who reported Wednesday in the journal Nature on three classes of odor molecules that could potentially keep mosquitoes away from people.  The chemicals work by blocking the mosquitoes’ ability to detect carbon dioxide — the key cue that leads the insects to their human victims.  Mosquitoes zero in on exhaled breath to find you and make you their lunch.

The types of odor molecules work in three ways.  The first set inhibits mosquitoes’ and flies’ carbon-dioxide receptors.  The second set mimics carbon dioxide.  The third set overstimulates carbon-dioxide-sensing neurons, making them unable to detect CO2 for several minutes.

Though the compounds haven’t yet been approved for use in humans, UC Riverside researchers think they might be used to create traps that could replace the bulky and expensive CO2-spewing models in use today.

“Odor molecules that mimic carbon dioxide activity … can lead to the development of small and inexpensive lures to trap mosquitoes — a great benefit, especially to developing countries,”  said Anandasankar Ray, an assistant professor of entomology at UC Riverside, in a press release.

The research, which included wind-tunnel experiments and other tests, tested the compounds on three disease-carrying mosquitoes: Anopheles gambiae (which transits malaria), Aedes aegypti (dengue and yellow fever) and Culex quinquefasciatus (West Nile virus and filariasis, also known as elephantiasis). The work was funded by the Bill and Melinda Gates foundation.

UC Riverside has patents on the discovery, which it has licensed to a new startup, Olfactor Labs.  The company plans to have product prototypes in 2012.

For more information about products currently available to ward off mosquito bites, check out this piece on natural repellents and this story on DEET drawbacks.  Read here for tips on choosing an insect repellant.

Los Angeles Times reporter Amina Khan wrote in April about efforts to engineer genes to fight malaria and in February about a mosquito subspecies that was making work harder for health workers.

By Eryn Brown, Los Angeles Times / for the Booster Shots blog