African Leaders Launch Malaria-Beating Scorecard

A coalition of African leaders on Monday launched a “scorecard for accountability and action” to track their progress in the fight against malaria, following on successes in battling the disease that claims hundreds of thousands of lives in Africa each year.

The 40-member African Leaders Malaria Alliance (Alma), which was launched two years ago, aims to bring malaria deaths to near zero across the continent by 2015 in line with United Nations Millennium Development Goals to improve health, reduce poverty and boost development in Africa.

“The evidence is becoming obvious. Malaria infection in Africa is receding,” Tanzania’s President Jakaya Kikwete told a press conference on Monday in New York for the launch of the scorecard.

He said in recent years 11 malaria-endemic countries in Africa have been able to slash malaria cases by 50 percent.

“The Alma scorecard is a good idea, and in our view it is a powerful monitoring tool because it involves the heads of state at the highest level of leadership and brings a collective focus of governments and partners in the fight against malaria,” said Dr. Luis Gomes Sambo, regional director for Africa of the World Health Organisation (WHO).

Targeted Measures

Kikwete partially attributed the successes to specific measures: distribution of bed nets, residual spraying of insecticide, rapid diagnostic tests and administration of combination drug therapy.

Since 2008, he said, 229 million long-lasting insect-treated bed nets have been distributed in Africa, which he said was sufficient to achieve 84 percent coverage of those at risk of contracting the disease. Homes covered by indoor, residual spraying of insecticide had increased from 20 million to 75 million over the past five years.

The Alma scorecard will be updated quarterly with data on key health metrics across several malaria-endemic countries to help African leaders hold themselves and each other accountable for progress in anti-malaria goals. It aims to spur decisive action among leaders and provide greater transparency in the efforts to fight malaria.

The scorecard will also track indicators for maternal, newborn and child health.

Still a Killer

Kikwete noted that malaria was Africa’s leading killer, affecting 170 million people on the continent each year. A child dies from malaria every 45 seconds, according to the WHO.

Malaria also hurts development, with two percent of Africa’s GDP lost each year because of the illness. Production of goods and services is disrupted and poor families end up spending 25 percent of their incomes for treatment, he said.

Despite successes in combating malaria, Kikwete noted that challenges remain. He said gains must be sustained, access to interventions scaled up and new sources of revenue identified. Also member countries and donor partners need to improve their compliance with commitments to fight malaria.

“We have guided our countries in making great strides in the fight against malaria and we remain committed to do whatever it takes to overcome the remaining challenges and win this war,” Kikwete said.

“Losing is not an option.”

Local Interventions

Among the most successful countries in the malaria battle is Rwanda.

Malaria deaths dropped by 60 percent between 2005 and 2010 through a rapid scale-up of malaria interventions, according to Rwanda’s health ministry.

Rwandan Health Minister Agnes Binagwaho attributed this to an integrated approach with community health workers.

“But more than that we have focused our activities where the people were dying and where people were sick at the community level,” she told Monday’s press conference. “We have a national policy for community health. Our objective is to keep 80 percent of any burden at the community level where people are living.”

She urged other African leaders to come up with homegrown solutions for country ownership in their malaria fight. “You cannot replicate,” she said.

She urged a greater regional approach to fighting malaria, because mosquitoes cross borders, and the creation of public-private partnerships so that bed nets could be produced within Rwanda and on the continent as a whole.

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Africa: 2011 Closes UN’s Roll Back Malaria Decade

Angolan Press

Luanda — The commemoration of the World Malaria Day this year marks the end of the UN’s roll back malaria decade and offers an opportunity for renewed commitment on the pandemic.

This was said Sunday by the World Health Organisation (WHO) regional director for Africa, Luis Gomes Sambo.

According to him, this affords us an opportunity to renew our common vision and commitment as we look forward and aim at attaining the Millennium Development Goals (MDGs) by 2015.

Malaria, by its complexity involving health as well as environmental and socioeconomic determinants and consequences, relates virtually to all the MDGs, the official also stated, adding that “as it is well known, our part of the world is home to an estimated 795 million people exposed to malaria. Close to 90% of deaths due to malaria worldwide occur in Africa.

Gomes Sambo went on to say that the poor, children, pregnant women, people living with HIV/AIDS, victims of unrest and disasters and non-immune travellers are particularly vulnerable. Therefore, progress in the fight against malaria in Africa is critical to reaching the ambitious targets set in the UN Secretary General’s call for Universal Access to essential interventions, the AU Abuja Declaration and Plan of Action, Resolutions of WHO Governing Bodies and the Roll Back Malaria (RBM) Global Malaria Action Plan (GMAP).

In this regard, he added, it is encouraging to note that malaria control alliances are being strengthened throughout Africa. For example, the African Leaders Malaria Alliance (ALMA) has committed to support elimination of preventable malaria deaths by 2015. The African Union and Regional Economic Communities have also kept malaria high on their health and development agenda.

Countries and partners are making commendable efforts to accelerate and sustain progress in malaria prevention and control in our Region. For example, endemic countries have reflected malaria control in their poverty reduction strategies, the official stated.

Programme reviews are ongoing and strategic plans are being updated to take into account funding and capacity gaps to reach universal access. The success rate for malaria proposals for the Global Fund (GFATM) reached 80% in Round 10. Consequently, effective interventions including protection from the mosquito vector through the use of Insecticide Treated Nets (ITNs) and Indoor Residual Spaying (IRS), prompt treatment of malaria cases using Artemisinin-based combination therapy (ACT), intermittent preventive treatment of malaria in pregnant women (IPTp) and infants (IPTi) are being adapted and scaled up, the WHO regional director also stated.

According to him, cross-border initiatives are catalyzing efforts to accelerate and sustain control and, where possible, to prepare for the transition to pre-elimination. The Affordable Medicines Facility for Malaria (AMFm) has been launched in Ghana, Kenya, Madagascar, Niger, Nigeria, United Republic of Tanzania and Uganda to ensure access to quality ACTs in private sector facilities. Malaria vaccine trials are ongoing in Burkina Faso, Ghana, Gabon, Malawi, Mozambique, Tanzania and Kenya.

As he went on to say, by the end of 2010, a total of 11 countries (Algeria, Botswana, Cape Verde, Eritrea, Madagascar, Namibia, Rwanda, Sao Tome and Principe, South Africa, Swaziland, Zambia and Zanzibar, United Republic of Tanzania) had registered more than 50% reduction in malaria cases and deaths; the proportion of households owning at least one insecticide treated net (ITN) was 42% and 35% of children under five years of age slept under an ITN; 27 countries had reported implementation of Indoor Residual Spraying (IRS) so that 73 million people accounting for about 10% of the population at risk of malaria in the Region were protected by IRS; 33 countries had adopted a policy of parasitological testing of all suspected malaria cases and 35% of malaria cases in the Region were confirmed by a diagnostic test.

In his opinion, in order to consolidate the gains achieved so far, “we need to ensure: rigorous governance to strengthen performance and accountability; mobilization of additional resources; linking disease programme development and health systems strengthening; better coordination of stakeholders and partners under national stewardship; and effective involvement of every exposed individual and community.”

Among the critical challenges that countries need to address are: weak surveillance, monitoring and evaluation capacity; inadequate operational research platforms; lack of implementation of regulatory measures such as the ban on oral Artemisinin-based monotherapies and inadequate monitoring of parasite resistance to antimalarial medications and mosquito resistance to insecticides, he stated.

Gomes Sambo pledged that WHO will continue to work with Member States and partners to mainstream malaria control in health and development policies and plans; mobilize domestic and external funding; foster public private partnerships, support alignment of stakeholders around country priorities and provide guidance and assistance to ensure efficient use of resources for performance and impact. We shall also continue to support initiatives for the removal of taxes and tariffs on malaria commodities, and a ban on the marketing of oral artemisinin monotherapies.

On the other hand, he called upon Governments, parliamentarians, Nongovernmental Organizations, the private sector, civil society groups, faith-based organizations and all exposed communities to take stock of our common achievements and mobilize financial and human resources in a decisive push to further accelerate malaria prevention and control for the socioeconomic progress of countries of the African Region.

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Genetically Modified Mosquitoes Offer Malaria Hope

By James Gallagher Health and Science reporter, BBC News

Scientists believe they are closer to being able to change the DNA of wild mosquitoes in order to combat malaria.

In the laboratory, they made a gene spread from a handful of mosquitoes to most of the population in just a few generations, according to a report in Nature.

If the right gene can be made to spread then researchers hope to reduce the number of cases of malaria.

Other academics have described the study as a “major step forward”.

The World Health Organisation estimated that malaria caused nearly one million deaths in 2008.

Spreading resistance

Around a million people are thought to die from malaria each year

Research groups have already created “malaria-resistant mosquitoes” using techniques such as introducing genes to disrupt the malaria parasite’s development.

The research, however, has a great challenge – getting those genes to spread from the genetically-modified mosquitoes to the vast number of wild insects across the globe.

Unless the gene gives the mosquito an advantage, the gene will likely disappear.

Scientists at Imperial College London and the University of Washington, in Seattle, believe they have found a solution.

They inserted a gene into the mosquito DNA which is very good at looking after its own interests – a homing endonuclease called I-SceI.

The gene makes an enzyme which cuts the DNA in two. The cell’s repair machinery then uses the gene as a template when repairing the cut.

As a result the homing endonuclease gene is copied.

It does this in such a way that all the sperm produced by a male mosquito carry the gene.

So all its offspring have the gene. The process is then repeated so the offspring’s offspring have the gene and so on.

In the laboratory experiments, the gene was spread to half the caged mosquitoes in 12 generations.

Defeating malaria

Professor Andrea Crisanti, from the department of life sciences at Imperial College London, said: “This is an exciting technological development, one which I hope will pave the way for solutions to many global health problems.

“At the beginning I was really quite skeptical and thought it probably would not work, but the results are so encouraging that I’m starting to change my mind.”

He said the idea had been proved in principle and was now working on getting other genes to spread in the same way.

He believes it could be possible to introduce genes which will make the mosquito target animals rather than humans, stop the parasite from multiplying in the insect or produce all male offspring which do not transmit malaria.

Professor Janet Hemingway, from the Liverpool School of Tropical Medicine, said the work was an “exciting breakthrough”.

She cautioned that the technique was still some way off being used against wild mosquitoes and there were social issues around the acceptability of using GM technology.

“This is however a major step forward providing technology that may be used in a cost effective format to drive beneficial genes through mosquito populations from relatively small releases,” she added.

Dr Yeya Touré, from the World Health Organisation, said: “This research finding is very important for driving a foreign gene in a mosquito population. However, given that it has been demonstrated in a laboratory cage model, there is the need to conduct further studies before it could be used as a genetic control strategy

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African Countries Warned of Drug-Resistant HIV

African countries need to take steps to monitor and prevent the spread of drug-resistant HIV. This was the warning from researchers at the annual conference on retroviruses in Boston last week.

Evidence presented to the conference showed that people who had never taken antiretroviral (ARV) medicine were increasingly being infected with HIV that was resistant to common ARVs.

They were probably infected by people who had either stopped taking ARVs or their ARV treatment had failed.

Countries where ARV programmes have been running for a long time were most likely to report drug-resistant HIV.

In parts of Brazil, for example, almost 20 percent of people tested had HIV that was resistant to at least one ARV.

In a study of almost 2 500 people in six African countries, drug resistance was highest in Uganda, which introduced ARVs earlier than the other countries surveyed, including South Africa and Nigeria.

At three Ugandan sites, almost 12 percent of people who had never been on ARVs before were infected with drug-resistant HIV.

Uganda was one of the first African countries to introduce ARVs, but in the mid-1990s some people were treated with one or two ARVs because of the exorbitant costs.

As the HI virus mutates easily, three different ARVs need to be taken at the same time every day for the patient’s entire life to prevent drug resistant HIV mutations.

In Uganda, there was most resistance to nevirapine and efavirenz, two of the most common ARVs used in Africa. Nevirapine has also been used for a number of years to prevent mothers from infecting their children with HIV.

PharmAccess, which conducted the African study, estimated that the risk of resistance increased by 38 percent for each year of ARV provision.

PharmAccess’s Dr Raph Hamers also reported on a study of young, newly infected Ugandans run last year which showed that over 8 percent had drug-resistant HIV.

A World Health Organisation (WHO) survey identified a number of factors that could drive the spread of drug-resistant HIV in Africa, including patients dropping out of ARV programmes, picking up their medication late and clinics running out of ARVs.

(AllAfrica)

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