Learning Reduces Blood Pressure, Scientific Study

Learning reduces blood pressure

Forget about the stress you go through during exams time in school. A study that has been published in the journal BMC Public Health, shows education reduces blood pressure and the reduction is even bigger in women than in men.

The British Heart Foundation said the findings supported the link between deprivation and heart disease risk.

The researchers suggest that blood pressure could be the reason why higher levels of education are generally linked to lower levels of heart diseases.

Now the technical:

  • Length of study 30 years
  • Number of people followed in the study 3,890
  • Study Groups: 3 [low education (12 years or less), middle education (13 to 16 years) and high education (17 years or more].
  • What was measured: The average systolic blood pressure for the 30 year period was then calculated.
  • Results: Women with low education had a blood pressure 3.26 mmHg higher than those with a high level of education. In men the difference was 2.26 mmHg.

Factors such as smoking, drinking and medication were taken into consideration

So what? ((Added commentary mine)

Does this mean you should pack and head for Harvard? Not necessarily. Some of us surely cannot or will not go back to school, but we can surely spend a day at the library over the weekend, read a challenging article in the local newspaper, or watch that intellectual discussion on the TV. Feeding your brain with diverse material will help reduce stress and worries which play role in blood pressure. And depriving your brain with such material will surely warrant the opposite effect.

And as for your children, give them the best start in life.

(Added commentary mine)

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Genetically Modified Fungi Prevent Parasite Development in Malaria Mosquitoes

spores of Metarhizium anisopliae in an oil formulation germinating on locust cuticle

K. Amponsah-Manager

A team of scientists in the UK and US have genetically modified a fungus that prevents the development of malaria-causing parasites in the mosquitoes.  The study which has been published in the journal Science showed that the fungus can eliminate up to 90% of the parasite in the vector that carry it, the female anopheles mosquito.

The scientists inserted the genes of human antibodies or scorpion toxins into a fungus called Metarhizium anisopliae and infected mosquitoes with the fungus. This conferred onto mosquitoes infected with the fungus the ability to block the development of malaria-causing parasites in mosquitoes.

The female Anopheles mosquitoes are the vectors for the malaria parasite, Plasmodium, which develop inside the body of mosquitoes. The mosquito simply helps to shuttle the parasite between infected person and healthy people and therefore the ability to deprive the parasite of its taxi service is key to fighting the illness.

Due to the environmental hazards of using pesticides to fight the malaria mosquitoes and the development of resistance to many anti-malarial products, recent years scientists have focused their attention on finding natural and environmental friendly methods to fight the disease. The fungus Metarhizium anisopliae naturally kills mosquitoes but unlike parasites, it takes day to accomplish that. The advantage of the Fungi’s patience is that because the mosquitoes can mate and do their usual chores, they have less reason to develop resistance.

Results of the study showed that malaria parasite survived in the salivary glands of 25 percent of the mosquitoes sprayed with the genetically modified organism, compared to 87 percent of those sprayed with an unmodified strain of the fungus, and to 94 percent of those that were not sprayed at all.

The good news from the study is the possibility that spraying malaria-transmitting mosquitoes with the genetically-modified fungus, also known as transgenic fungus, could one day become a feasible method to significantly reduce the transmission of the disease to humans.

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Is Kenyan African Silicon Valley?

CHRISTINE MUNGAI

Kenya is on the brink of becoming Africa’s ICT hub due to the continued growth in Internet and mobile technology use in East Africa’s biggest economy with investors flooding the country.

The recent Kenya Economic Update report by the World Bank states that over the last decade, ICT has outperformed all others sectors in Kenya, growing at an average of 20 per cent annually.

“The benefits of ICT are starting to be felt in other sectors, and have contributed to the conditions for the country to reach an economic tipping point,” the report says.

The report reveals that Kenya has opened 2011 with renewed and stronger than expected growth on the back of a new constitution, strong macro-economic policies, and a favourable regional environment.

Over the past three decades, Kenya has experienced only two short periods of economic growth that exceeded five per cent and was sustained for at least three consecutive years: 1986-88 and 2004-2007.

This has raised the question: Is Kenya on the verge of experiencing another growth spurt? Will it last longer and go deeper than the previous two episodes?

The World Bank researchers envision that this could indeed be the case, as the uptake of ICT throughout the economy could provide the impetus required for high and sustained growth.

Today, Kenya has the largest mobile money platform in the world. An estimated 15 million mobile phone users were using mobile money by the end of 2010, the equivalent of three out of every four adult Kenyans.

In East Africa, Internet access in recent years has recorded a significant growth.

The World Bank estimates that in 2004, there were 1.65 million active Internet users in the region.

By 2007, the number had increased to 4.78 million, and by 2010 the number of regular users had jumped to 6.78 million, a penetration rate of about 5.1 per cent of the population.

The introduction of data enabled smartphones, which allow internet access through mobile phones has boosted this area hugely.

Kenya’s active Internet usage stands at 8.7 per cent of the population, the highest in the region, compared with Uganda (7.9 per cent), Rwanda (3.1 per cent), Tanzania (1.2 per cent) and Burundi (0.8 per cent).

Paul Odhiambo, CEO of a Nairobi-based ICT consultancy firm, says that creating demand for locally developed software will provide a much needed stimulus for growth of the sector.

“If the government passed similar policy as was passed regarding local content on television—that a certain percentage of ICT solutions in government institutions must be home grown—this will go a long way in developing our local ICT talent.”

Mr Odhiambo says the region needs to develop confidence in its own human sources.

“What we need is to believe in our ability to make this sector really take off, and deliberately create demand for local solutions. We must invest in our own,” he says.

Those that actually need the Internet the most are the very poor people,” says Dr Bitange Ndemo, Permanent Secretary in the Kenya Ministry of Information and Communication.

He believes that the government should step in and make ICT infrastructure an open access platform, just like the road network. “This is the only way prices will come down.”

Last June, Kenya’s telecommunications regulator slashed the licence fee for third-generation (3G) mobile Internet services by 60 percent to $10 million to raise penetration, and announced that it would not charge for an upgrade to 4G.

The wider applications of ICT are starting to reshape the structure of the economy, especially in the financial sector.

In 2010, this sector benefited from a number of innovations, including Equity Bank and Safaricom’s M-Kesho, a joint venture allowing mobile phone users to earn interest on their mobile phone-based savings accounts.

In agriculture, for instance, an SMS platform is used to disseminate information on commodity prices allowing farmers to make better decisions regarding their produce.

The platform also allows disease tracking and consultation to enable communities isolated from healthcare infrastructure to diagnose and treat diseases.

Civil society organisations have also effectively used mobile technology to monitor social unrest and human-rights violations, mobilise voters and disseminate election results, and even track the management of local budgets.

All this is not without challenges. Last December, for instance, a number of fibre optic cables that run around Nairobi were dug up in the middle of the night and severed, causing communication blackouts.

The attacks were blamed by many on digital turf wars between rival firms, keen to seize any advantage in the emerging broadband market.

Others blamed disgruntled employees.

CHRISTINE MUNGAI, The East African

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South Africa, Nigeria and Kenya are Top Three in Science in Africa

 

Gatonye Gathura

Nairobi — Kenya is ranked third in the production of new scientific knowledge on the continent.

 However, this is not enough to propel the country into a knowledge-based economy or out of poverty, says the 2010 Science Report to be launched in Nairobi on Friday morning.

Kenya was among the top three publishers of scientific publications from sub-Saharan Africa between 2005-09.

The country also rates highly in the application for patents with the US Patents Office and is third on the continent in Internet access after Sudan and Zimbabwe.

But a close scrutiny of the scores shows little cause to celebrate. While Kenya made 24 patent applications within the study period, the Unesco report shows South Africa as having acquired 465 patents.

South Africa publishes almost half of all scientific articles in the sub-continent, followed by Nigeria (11 per cent) and Kenya (six per cent).

This low performance in science and technology is blamed on poor university education, little investment in the sector and increasing cases of brain drain.

To check on brain drain, Kenya has been encouraged to borrow from Fifa, the world football governing organisation, which allows players in foreign countries to appear for their countries for national duty.

What is now being referred to as the “fifarisation” of brains was mooted in Nairobi in March.

Entitled by law

In such an arrangement, a Kenyan scientist or researcher working abroad would be entitled by law to return home to undertake a certain assignment of national importance.

“Once their mission was accomplished, they would return to their working stations.

“In this way, a team of medical professionals working in the US and Europe, for instance, travel home once in a while to share their knowledge and skills,” says the report.

A look at the subjects local researchers are publishing, the report reveals a narrow spectrum of study areas making the country a net importer of skills in the science industry.

“In Kenya, the life sciences, which include clinical medicine, biology and biomedical research represented as much as 93 per cent of scientific articles in 2008, compared to four per cent for earth and space sciences.

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Seaweed May Provide Clue to Fighting Malaria Parasite

By Steve Connor, Science Editor, The Independent

A red seaweed found off the Pacific island of Fiji has been found to contain a powerful class of natural substances that can effectively destroy the malaria parasite, scientists said yesterday.

The first laboratory tests have shown that the substances are toxic to the Plasmodium falciparum parasite which causes the most dangerous form of malaria and is developing disturbing resistance towards existing drugs.

Researchers believe that the substances, called bromophycolide compounds, are produced by the seaweed as a chemical defence against attack from marine fungi. But they also appear to be effective against the malaria parasite, said Julia Kubanek of the Georgia Institute of Technology.

“The seaweed is marshalling its defences and displaying them in a way that blocks the entry points for microbes that might invade and cause disease. Seaweeds don’t have immune responses like humans do. But instead, they have some chemical compounds in their tissues to protect them,” Dr Kubanek said.

“The bromophycolide structural class is unique… there are no antimalarials like it. Even though it looks like the mode of action may be similar to that of chloroquine and other quinine antimalarials, our bromophycolides are effective in vitro against a chloroquine-resistant strain,” she said.

“That means that the resistance mechanism that the parasite has evolved to the quinines does not work against bromophycolides,” she said.

One of the most powerful anti-malarial drugs at present is artemesinin, which was derived from a shrub used in Chinese herbal medicine, but in some regions of the world drug-resistance has already developed against it, which is why scientists are interested in finding alternative anti-malarials.

The tests in the test tube need to be repeated in animal models before the drug, which can be synthesised in the laboratory, can be used in clinical trials, Dr Kubanek said.

“We need to show that bromophycolides are effective in a mammalian model, since no in vivo work has been done yet. We may need to design a more potent and more selected derivative, since even in vitro we see effects on non-parasite cells,” she said.

“Bromophycolides are not as potent as artemesinin and we don’t yet now how fast they work in humans, or even if they work in humans. So much work is left to be done. But we are hopeful that we will be able to design a strong antimalarial from this lead,” Dr Kubanekadded.

Meanwhile, scientists have warned against the spread of a new Madagascan malaria that infects previously immune individuals, threatening a new scourge of infection. The strain of Plasmodium vivax has broken through a natural genetic barrier that until now has protected millions of Africans.

Scientists say there are already signs of the strain spreading from the island of Madagascar to the east African mainland. In some regions they believe it could take over from Plasmodium falciparum as the continent’s dominant malaria strain.

Seaweed clue to fighting malaria

The Press Association

A tropical seaweed may provide scientists with a new weapon against malaria, research has shown.

Chemical compounds used by the seaweed to ward off fungal attacks have shown promising activity against the malaria parasite in the laboratory.

Researchers now hope to test the most effective compound in mice.

They are also trying to synthesise a more potent artificial version of the chemical.

New drugs are urgently needed to combat the malaria parasite, which has developed resistance to most available treatments.

Each year malaria kills around one million people around the world, mostly in poorer regions such as sub-Saharan Africa.

The anti-fungal compounds were found on the surface of Callophycus serratus, a seaweed found in waters off the Fiji islands.

Scientists spoke about the research at the annual meeting of the American Association for the Advancement of Science in Washington DC

Study leader Dr Julia Kubanek, from the Georgia Institute of Technology, said: “The language of chemistry in the natural world has been around for billions of years, and it is crucial for the survival of these species. We can co-opt these chemical processes for human benefit in the form of new treatments for diseases that affect us.”

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Your Expectations Can Determine Whether a Drug Works for You

Your can manipulate your thought to determine the effect of drugs

A positive attitude in life is not only essential for career development and success, in fact according a new study published in Science Translational Medicine, pessimism can determine whether a drug works for you or not. According to the study, a patient’s belief that a drug will not work can become a self fulfilling prophecy.

What this means that if one expects that a tablet of ibuprofen will do nothing to alleviate his or her pain, the body may actually not experience any benefit from taking the pill. Simply put, you can change the outcome of the drug by manipulating your thoughts and expectations. It all boils down to the state of mind.

I’ve summarized the study for you below

The experimental Setup:

The researchers assembled 22 patients for the study. At the beginning of the experiments, heat was applied to the legs of the patients. On a scale of 1 to 100, the patients were then asked to report the level of pain. Then the patients were attached to an intravenous drip in order to administer drugs to them in secret.

The Result:

The initial average pain rating was 66. After the patients were given remifentanil, which is a potent painkiller, without their knowledge, the pain score went down to 55.

They were then told they were being given a painkiller and the score went down to 39.

Then, without changing the dose, the patients were then told the painkiller had been withdrawn and so they should expect pain. The score went up to 64.

So even though the patients were being given remifentanil, they were reporting the same level of pain as when they were getting no drugs at all.

The conclusion (mine)?
Your brain or state of mind plays a big role in the way you perceive pain, feel your environment and even acknowledge the effect of sickness. In essence, there is a cognitive side of sickness.  If the magic pill that works for everybody isn’t working for you, it may be time to recondition your thought rather than switch doctors or blame the drug manufacturer.

But the bigger picture here is the need to acknowledge how pessimism can derail your progress in several facets of life.  If nothing is working, it may all be in your mind.

Begin to think positively; you won’t lose anything if you find out your were wrong. Someone once said

“In the long run the pessimist may be proved right, but the optimist has a better time on the trip.”

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A Smelly Experiment: Mosquito-Eating Spider Likes Smelly Socks

Not the most appealing-looking house guest, but it could help combat malaria
Victoria Gill

A spider that preys on the malaria-carrying mosquito Anopheles gambiae is attracted to the odor of sweaty socks, according to a study.

Scientists in the UK and Kenya used previously worn socks in an experiment to find out if the spider, like its prey, was attracted to human odors.

The jumping spider appears to have evolved an affinity for smelly human feet in order to help find its prey.

The team reports its findings in the journal Biology Letters.

They say that people might be able to “recruit” this East African jumping spider, Evarcha culicivora , in the battle against malaria by encouraging the arachnids to live in their homes.

Smelly experiment

Fiona Cross, from the University of Canterbury, and Robert Jackson, from the International Centre of Insect Physiology and Ecology (ICIPE) in Kenya, carried out the study.

They were interested in this species because it is the only known predator that specifically preys on blood-carrying mosquitoes.

“We had a suspicion that human odor was attractive to the spiders before we even ran the experiment,” Ms Cross told BBC News. “We generally find these spiders in the tall grass next to houses or other buildings occupied by people.”

To test this suspicion, the team devised an aroma-based experimental set-up called an olfactometer.

They put each “test spider” into a small holding chamber into which air was pumped, either from a box containing a clean sock or one containing a worn (and therefore

The jumping spiders can kill 20 mosquitoes in one "feeding frenzy"

smelly) sock.

Each spider was able leave its holding chamber at any time and escape into an exit chamber, which did not have sock-scented air pumped into it.

The spiders supplied with the aroma of worn socks always remained in the holding chamber for longer than those exposed to the freshly washed sock.

Ms Cross said it was “unprecedented that a spider should find human odour attractive”.

But, she added, the discovery tied in with some of the spiders’ remarkable behaviour.

“When they smell blood, they can launch into feeding frenzies where they kill up to 20 mosquitoes in rapid succession, and not necessarily to eat all of them,” she explained.

“We need to learn more about why they do this – they really do go quite crazy when they are in the vicinity of blood.”

Anti-malaria arachnid

It may be a rather ugly, bloodthirsty little creature, but Evarcha culicivora could help in the ongoing and complex battle against malaria.

“It’s something that’s there in the environment for free,” said Ms Cross. “So why not do what we can to find out about this remarkable predator?”

She and her colleagues are currently trying to find out what exactly people might be able to do to attract the spiders into their homes, without also attracting the mosquitoes.

The scientists say that, in malaria zones, people should welcome these particular creepy crawlies into their houses.

(Read the Scientific Article From Biology Letters)

(Victoria Gill, Science and nature reporter, BBC News)
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The Role of the AU in Science and Technology Development in Africa

Here, we discuss some of the tasks the African Union (AU) can pursue in the area of Science and Technology (S&T) to bring prosperity to the African continent. The AU was formed from the Organization of African Unity in 2002, with a new vision of “An integrated, prosperous and peaceful Africa, driven by its own citizens and representing a dynamic force in the global arena.” In other words, the current African Union (AU) has the mandate to facilitate the search for solutions to the existing and emerging problems of African countries so as to quicken the pace of development. But then, what is going to be the method for development? Is it going to be by orthodox economic methods or by innovation through science and technology?

Africa’s Science and Technology Consolidated Plan of Action makes it clear that, the African Union (AU) acknowledges Science and Technology (S&T) as prerequisites for the rapid transformation of African economies, and to a level that positively impacts the standards of living of the majority of Africans. However, despite the series of meetings, which have occurred over the years to generate ideas to use S&T for Africa’s development, little has been achieved in terms of the general improvement of the standards of living of the African people. That is to say, if the AU only makes recommendations for individual countries to carry them out without taking the responsibility of accomplishing some of the tasks itself, it may be difficult for Africa to meet the millennium development goals (MDGs). Here, I suggest that that the AU also assumes an active role of promoting or establishing Research and Development (R&D) in the area of Science and Technology (S&T). In the ensuing discussion, we shall look at ways the AU can accomplish that for the benefit of the people of Africa.

Almost all countries in Africa are saddled with the common problems of underdevelopment, which we are all aware of, but the information that is not readily available is how efficient different countries in Africa are attempting to solve these problems. So, one of the tasks for the AU will be to compile statistics that identifies countries within Africa, which are able to use S&T to solve the problems of underdevelopment effectively. The R&D facilities in these countries are then assisted by the AU to do intensive and more sophisticated work to increase knowledge in that area of their expertise for the benefit of all Africans. For instance, in Africa, malaria is generally a serious problem, but the capacity to research on malaria to come up with effective solutions may not be available in all countries. This means, it will be prudent for the AU to identify African countries with the infrastructure and research expertise in malaria and assign them the task (with the appropriate resources) to do R&D in malaria for the whole of Africa. In other words Africa will be practicing division of labor with its limited resources to solve some of its key problems.

On the other hand, some of these key problems facing Africa can be solved in the shortest possible time when they are pursued by research and development (R&D) facilities set up by the AU, because these centers of excellence will have the state of the art equipment and highly skilled human resources drawn from across Africa and the developed countries. Currently, some of the key problems pertinent to the development of Africa and the well-being of Africans are in the area of Food Security, Primary Health Care and Energy. Interestingly, these problems can be tackled head-on with Science and Technology. We shall attempt to explain why it will be beneficial to the African people if the AU tackles these problems directly.

Food security means the continuous availability and accessibility of adequate, safe and nourishing food to the people of a country (adapted from WHO). From this definition, we can infer that food security may be a world-wide problem. But for the purposes of this article, we shall limit the discussion to Africa. Currently, Africa has a significant number of undernourished people simply because Africa is not producing enough to feed its people. The reasons for the low production are many, but the main one being the low usage of S&T to transform Agricultural production. We are still depending on rain-fed agriculture, planting crops and rearing animals, which have little resistance to diseases and using outmoded equipment for farming. These prevailing conditions are huge problems which may be difficult to overcome by anyone country and so the AU can step in by establishing facilities (R&D) to develop or adapt to technologies which will dramatically improve yields of food. Such technologies are then passed on/disseminated to individual countries to use. The AU must as well set up policies, which will ensure that these technologies are applied in member countries to increase food production and improve food security.

A high percentage of the health care budget of many African countries deals with preventable diseases. In other words, the Primary Health Care of African countries are more concerned with preventable diseases – mainly communicable diseases. This is not an acceptable situation, because scarce resources which should have been invested in other areas of the health care delivery (for example R&D, training and treatment of non-communicable diseases like cancer, heart disease, kidney disease, diabetes and the like) are devoted to otherwise preventable causes. If we assume that, to a large extent, the governments of Africa are doing their part in educating the public on preventable diseases, then the problem of high expenditures on preventable diseases will more likely be due to the lack of enough or quality medicines to treat the diseases. Incidentally, both of these conditions potentially result in resistance strains of the causative micro-organisms, which further compound the situation, so this is where the AU comes in. It can tackle the problem in two ways, namely, the development of generic drugs in Africa and/or the development of our local medicinal plants. The AU has already taken a bold step in pushing for the idea of development of generic drugs in Africa and a couple or so of African countries like Cameroon have started pursing the idea. The hard fact is that, even in the long-term, only a handful of African countries may be able to pursue this initiative, so what I think has to be done is for the AU to have a regional research and production centers, which will look into developing appropriate technologies for the generic drugs and local medicinal plants, for use by African countries and for export.

Many African countries have not been able to meet their energy needs and that still appears a formidable task for the individual countries to handle. Most of them depend on hydropower for their energy sources, but this source in itself has contributed to the unstable energy supply in African countries. This is because, during droughts volumes of water decrease, and as a result, the amounts of energy being generated from such sources also reduce – sometimes to about 50% or more of the maximum capacity. This means that, alternative renewable energy sources must be explored, for example wind, solar and biomass. But, because it is a heavy task for many individual African countries to pursue, the AU must play a role in it. It can set up an R&D to research into alternative ways of developing clean and renewable energy for Africa as well as for export. Currently, alternative forms of clean and renewable energy development are attractive areas of investment for many countries around the world and the AU can bring a lot of business to Africa if it takes part in that business.

As we are aware, Africa is endowed with a lot of natural resources, that include oil and minerals, which are largely untapped or exported as raw materials. Governments are aware that if they export processed natural resources they stand to gain in terms of more foreign exchange and creation of jobs for the people of the country. However, the situation of exporting unprocessed natural resources has not changed much since the 20th century, and future prospects are not well defined. And so, what can be done to improve this situation is to have the AU set up R&D facilities and huge industries across Africa, which will seek to research and process our raw materials before exporting them. Such activities are likely to bring huge foreign exchange to the continent and create jobs for many Africans.

All these initiatives suggested here, and to be carried out by the AU, will enhance the S&T capability and capacity of Africa. Consequently, they will attract heavy foreign investment, significantly improve the quality of our exported commodities, create more jobs and improve the well-being of people in Africa. The AU will be able to better accomplish these tasks, if it is well resourced, and so the members must consider setting up and contributing to a fund, which will catalyze the projects the AU will undertake for the benefit of the people of Africa. Please look out for the next article.

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