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The recent ‘people’s revolt’ against the ousted President Hosni Mubarak of Egypt started on facebook and twitter. Politics and all its contents and discontents now find relevance mostly on the internet. In fact, no web attention, no politics. Politicians have also seized the opportunity of technology to promote their ideas and raise awareness about their policies. President Goodluck Jonathan of Nigeria made his first declaration to contest 2011 elections on the Facebook. We should have known that the time would come when ‘techno-democratic forces will drive silent revolutions across the globe’ (Tunde Oseni The Economist, 19 June, 2008).
This is the era of political technology (not necessarily in the Michel Foucault way please) and technological politics! It reached the peak when, for the first time in history, a presidential candidate, Senator Barack Obama, as he then was, raised a youth-focused campaign from Chicago to reach the nooks and crannies of the United States. Obama literally started it!
Not only was Senator Obama able to use the internet as a political technology, he also changed the way and manner politics was played. For the first time, a presidential candidate raised millions of dollars via the internet. With oratory prowess and a highly electrifying message of change and hope, Senator Obama changed the face of politics. Before other candidates could realize the power of politics in technology and the power of technology in politics, Obama had raced over. While they were too busy with the old idea of political marketing, Mr Obama had raised several volunteers and foot soldiers from millions of facebooking and twittering youths. While his opponents were using analogue, Mr Obama had gone digital.
Digital democracy is now moving fast across the world. The internet is now the most important tool of politicking. Those who want to catch the majority of their constituents, which in most cases are the youths, have come to terms with the inevitable use of the internet. It is no longer enough to have good ideas; you have got to sell them digitally. It is no longer enough to claim follower-ship; you have got to tell us online. Leaders are now seen in the image which the internet users create for them. No doubt, the cyberspace is limited in developing countries, and could be a very rowdy space for cacophonous views and counter-views, but the cyberspace has come to be a very significant avenue for democratic political mobilization.
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This article looks at several other methods the government of Ghana (and that of other African countries) can explore to quicken the pace of Science and Technology (S&T) development in their respective countries. For a systematic development in any field, there must be a well formulated policy/plan which seeks to guide the field. The necessary adjustments to the policy/plan are then made with advancing knowledge in the field. That is for Ghana and other African countries to make a leap in S&T, they need to have a sound S&T policy in place. Such a policy should be partly guided by the type of technology they wish to develop in their respective countries. Broadly speaking, two forms of technology could be available to a country and they are the Borrowed Technology (BT) and Indigenous Technology (IT). The former, as the name implies is a type of technology which is accessed from another country whilst the latter is developed in the home country.
Ghana and other African countries need to be clear about the direction they are taking as far as the two types of technology are concerned because, that will largely guide the nature of Research and Development (R&D)they set up. The question then is, do African countries stick to the Borrowed Technology or the Indigenously Developed Technology, or use both of them simultaneously? Definitely, we cannot move away from developing our Indigenous Technology, because we need that to be able to process many of our raw materials that we consume and export. That is to say, the Indigenous Technology, when well-developed has several advantages including development of skills of the labor force, availability of jobs and reduced prices of consumer products. However, IT alone may not be enough to keep up with the technological demands of our growing economies and especially improve the standards of living of people in the short-term. And so in addition to the IT, African countries can borrow technology from scientifically and technologically developed countries, adapt and possibly improve such technology to suit their environment(s). For instance, one area of importance to many African countries is improving farm yields, and currently we are aware that Biotechnology among others has the power of accomplishing that task. So if such a technology is available we can establish an R&D to adopt and adapt it to our benefit – saving us the trouble of researching from the scratch. In other words, it will be a good idea if African countries formulate policies, which make use of both Indigenous Technology and Borrowed Technology simultaneously, which in turn is expected to guide planning and investments in R&D related to S&T development.
Funding is required to develop Indigenous Technology and properly use Borrowed Technology. Especially in the Borrowed Technology situation, expertise would have to be sought at a cost probably from the country or countries which have developed the technology. To minimize the costs for such technology transfers, the government of Ghana (and that of other African countries) should seek to form bilateral relations in science, technology and innovation with the industrialized and newly industrialized countries. Under such bilateral relations, we can benefit from among others, training of our personnel, sharing of technologies, solving of common problems together and systematic development of capacity and capability for science and technology. Such bilateral relations should also seek to actively establish research and training centers of excellence in Ghana (and other African countries). The African Union (AU) is poised to encourage the development of S&T in Africa and harmonize emerging technologies and innovations among member states, which is a good first step.
Funding for R&D in Science and Technology (S&T) can come from three main sources: the private sector, government funds and foreign loans. It is very helpful when the private sector contributes significantly to R&D development of a country because that means the private sector is robust and is building the skills of the labor force and creating jobs. However in Ghana, private sector contribution to R&D is very small (less than 5%) compared to about 40% or more in industrialized and newly industrialized countries. Government funding of R&D through locally generated funds is economically wise for the main reason that the government tends to dictate its scale of preference for projects and their funding. However, in the last case of funding R&D with foreign loans, there could be a problem in that the lender usually sets up guidelines for the use of the money and that could conflict with the priorities of the government and indeed the country. This situation can lead to stagnation or even retrogression in S&T growth. So it is advisable that government tries as much as possible to generate funds from its local resources to pursue R&D in S&T programs.
Process Plant Technology is a South African technology company, based in Johannesburg.
It must be understood that many of the countries which have excelled in S&T have devoted considerable amount of resources to R&D and currently, the percentage of Gross Domestic Product (GDP) invested in R&D is an important parameter in measuring technological advancement. That is, in those countries with high science and technology development, investments have been between 1 – 4 % of their GDP. South Africa is investing close to 1% of its GDP in R&D and it appears to be the only country in Sub-Saharan Africa with advanced development in Science and Technology. In Ghana and in many other African countries, the percentage GDP invested in R&D has been below 0.5% and consequently, the level of S&T development in such countries has been poor. The African union (AU) recommended that African countries strived to achieve an investment of at least 1% of their GDP in R&D by 2010, but it is not clear how many African countries were able to meet that goal. It is imperative that African countries strive to achieve that goal and go beyond that in the short-term as part of their commitment to use S&T to transform the economies of their countries.
As we mentioned above, in Ghana, the contribution to R&D development from the private sector is very small. This does not augur well for development of S&T especially in the circumstances where government funding to that sector is also weak. Government must take bold steps to encourage R&D in industries by creating a congenial atmosphere for that purpose. It must also put in place measures which do not favor wholesale import of semi -finished goods to be assembled to finished products in Ghana – some of the key reasons being that, importation of semi finished products takes away research and development (R&D) from the local industry, diminishes technological advancement and reduces job creation, which are bad for the economy. So government must rather encourage imports of raw materials (if they cannot be found locally); and process such raw materials in Ghana to finished goods for consumption locally or for export.
One area lacking proper coordination and management in Ghana and other African countries is harnessing innovative ideas from academia and translating them into industrial products. To address that, government must set up an innovation and technology transfer office to oversee such creative endeavors. Such an office, among others will seek to minimize the bottlenecks which come up during the process.
These are few suggestions which will impact on the S&T development in Ghana and other African countries. Please look out for the next article.
This article will be focusing on tertiary education with emphasis on the universities in Ghana and how they influence the development of Science and Technology. Most of the points which we shall discuss are also shared by universities in other African countries. In Ghana, the National Council for Tertiary Education (NCTE), under the Ministry of Education is directly responsible for managing tertiary education institutions. The universities are established to teach, educate, research and develop innovative ideas for the benefit of society, but depending on the resources a university has, its role may just be a partial fulfillment of the above functions.
Since the establishment of our public universities (University of Ghana, University of Science and Technology, University of Cape Coast) decades a go, there has been very little discussion about redesigning the curricula at the universities to specifically meet the demands of Science and Technology development in Ghana. Essentially, the same content of science syllabi has been taught over decades and may partially explain our present level of development in Science and Technology. The university graduates who have been produced by this system are not well suited to provide the necessary inputs for the Science and Technological development of our nation. In other words, they are unable to contribute effectively in that direction and the situation is not peculiar to Ghana, but to many other African countries. We need to take a critical look at the academic content of our science syllabi at the universities and restructure them to solve the problems of our country. To achieve this, academia and our local industry should foster good relationships so as to be able to identify specific problems in Science and Technology that need to be addressed in Ghana. The scientific and technological problems identified should then be reorganized and translated into a significant part of the lab and project work done at the universities. Such lab and project work will give room to students and professors alike to research and come up with solutions. A student who has graduated with such expertise is relevant to the economy because his or her skills can be directly employed or deployed to contribute to the Science and Technology development of the country.
This brings into question the state of funding at the universities to pursue Research and Development (R&D). Currently sources for funding R&D at the universities in Ghana mainly come from the government subvention, the GET fund and local industries. But contributions from these sources have not been enough to kick-start vigorous R&D in Ghana. I am suggesting here that a Research and Development Fund (RDF) is set up by the Ghana government and the government must be committed to contributing a reasonable percentage of the Gross Domestic Product (GDP) of Ghana into it annually. This must be seen by the government as building the capacity and capability for Science and Technology development in Ghana. The rest of the contributions to the fund must come from local industries, the African development bank, universities and countries with economic interest in Ghana as well as philanthropists. Researchers will have access to funds from the RDF by developing research proposals (which should contain among others, the objectives of the research, methods to pursue the research, expected outcomes and amount of funds needed for that purpose) and submitting them to an independent body for consideration. Such a body should be made up of varied professionals such as science professors, entrepreneurs and social scientists who are knowledgeable in their field. One key requirement for awarding grant money to an applicant will be that the proposed research should seek to address some of the key problems of our country. To efficiently manage the funds, it will be the duty of government, policy makers and fund administrators to have a scale of preference in place to determine which areas of Science and Technology need urgent funding and/or more funding. Establishment of a robust RDF will be one of the few but effective ways of creating an enabling environment for research into Science and Technology in Ghana. In line with the above, the Government of Ghana should set up a Research, Technology and Innovation center (RTIC) at the universities if it has not already done so, to see to the patenting of ideas which come out of such pursuits and transfer the technology as appropriate.
Funding is not the only factor that limits research. In fact adequate time is also a requirement for research. Where the student: faculty ratio is large (that is a large student population compared to the number of professors), professors have little time to engage in research. This is because the professor spends most of his or her time meeting with students who need assistance and the rest of the time for marking/grading papers. To partially alleviate the situation so as to be able to create some time for research, I recommend the following: first, conditions should be created such that professors teach continuously and intensively for at most two semesters and then the third semester is devoted to intensive research – that is, alternating two semesters of teaching and one semester of research. Second, I recommend that we de-emphasize the essay question format. This is because the essay question format usually requires the experience and knowledge of only the lecturer to mark/grade and can involve a great deal of time if it is to be done objectively, whereas other formats like multiple -answer question could be graded by the Teaching Assistants (TAs). Thus, in any examination we can limit the essay-type questions to about 50 % or less, the professor then provides answer keys for the rest so that TAs can mark/ grade them.
Generally, because of the fast pace of research discoveries in Science and Technology in the developed world, there could be a gap in scientific/technological knowledge between professors in the developing and developed countries – with the professors in the developing countries being at a disadvantage. This calls for several measures. The most basic is that the universities must subscribe to leading journal publications from America and Europe. These publications must be made available in electronic form so that both students and professors can have easy access to them, and it is important that both of them read the material. Seminars must be regularly organized to give room to both students and professors to discuss latest information they have read and gathered from the journals. This will partially bridge the information gap. I am also proposing that, it is about time we look into making some of our professors in the developed countries adjunct professors in our local universities. What that means is that, such professors in the developed countries will be attached to our local universities and they will spend about a month or so annually teaching at our universities. The adjunct professors will help build syllabi, teach and give seminars in areas they think are “new” in their field. This is intended to bridge the science information and technology gap between the developed and developing nations like Ghana. After all, this is not a new concept in other fields – especially soccer. When Ghana and other countries are going to play international games, they invite seasoned professionals playing in other countries to join the national team so as to increase their chances of winning. So we can employ the same technique here with our skilled science and technology professionals in the developed countries.
It is not clear whether the universities in Ghana (and for that matter other African countries) have a reward system in place for the professors teaching and researching on Science and Technology. Here, it is suggested that a well formulated reward system be put in place to acknowledge professors who are able to contribute to the development of Science and Technology in Ghana. Specifically, the system must identify and reward professors who are able to develop innovations which can lead to or has led to better technologies to teach science, process food and medicinal plants, increase the yield of animal and crop farming, tap into wind, solar and biomass energy… just to mention a few. And the reward should come in the form of good salary, research funding, equipment and larger laboratory space.
These factors are likely to attract and retain good professors, and catalyze the Science and Technology development in Ghana and other African countries. Please look out for the next article.
Johannesburg (South Africa) – African chemistry is booming, according to scientists who gathered this week at a conference in Johannesburg from across the continent to kick off the International Year of Chemistry 2011 (IYC2011).
The past decade has seen growth in African chemistry, fuelled in particular by the classification and investigation of natural products, according to James Darkwa, who chaired the Chemistry — the Key to Africa’s Future conference (16–21 January).
But, despite the recent boom in African chemistry with several continental and regional networks springing up, sustainable funding for research and maintenance of laboratory equipment remains a big challenge, SciDev.Net heard on the sidelines of the conference.
Alejandra Palermo, international projects manager at the UK’s Royal Society of Chemistry (RSC), told SciDev.Net that a particular challenge is maintaining and accessing laboratory equipment, as there is a lack of engineers, spare parts and chemicals.
And Darkwa, a chemistry professor at the University of Johannesburg told SciDev.Net that sustainable funding for chemists remains a challenge.
However, Darkwa said that the new chemistry networks could now help bring these issues to the attention of African policymakers and help chemists collaborate on finding solutions.
Members of one such network, the Pan Africa Chemistry Network (PACN), told SciDev.Net there were several success stories since its launch in 2007.
Jean Claude Ndom from the University of Douala, Cameroon, was sponsored by PACN and the São Paulo Research Foundation for a two-month research fellowship in the Brazilian capital, which resulted in several long-standing collaborations.
“PACN is not only bringing together African chemists but also chemists around the world,” he said.
Meanwhile, the Chemical Society of Nigeria has received 2,000 books through PACN, said Yilkur Lohdip, the society’s external relations officer, and travel grants and networking meetings have been popular.
PACN has also identified centres of excellence to act as regional training and research hubs.
“This is the right way to get African chemists on the world map of chemistry,” said Anthony Gachanja, professor of chemistry at one of the excellence centres — Jomo Kenyatta University of Agriculture and Technology, Kenya.
Another network, the Botswana-based Southern and Eastern Africa Network of Analytical Chemists, has helped chemists communicate their research findings and identify colleagues on the continent, according to Darkwa.
“The network allows people who don’t have resources to go to labs that are better equipped,” he said.
The conference took place alongside the 40th South African Chemical Institute convention and the third meeting of the Federation of African Societies of Chemistry, where chemists examined sustainable use of chemistry for development and better research links on the continent.
It was also the first in a series of worldwide events that mark IYC2011 — an initiative campaigned for mainly by Ethiopian chemists — which will be formally launched at UNESCO headquarters in Paris next week (27–28 January).
This article will be focusing on pre-tertiary education in Ghana and how it influences the development of Science and Technology. Parallel examples would be drawn from other African countries as appropriate.
The Ghana education system and that of many other countries can be divided into two main areas: pre-tertiary and tertiary education. In Ghana, the pre-tertiary is managed by the Ghana Education Service (GES) whereas the tertiary is managed essentially by the National Council for Tertiary Education (NCTE). How do we define education? There are several definitions available, but I will define education as a systematic development of the human mind through a measured exposure to information and reasoning.
For decades, the educational system of Ghana and that of the West African Examination Council (WAEC) member countries were based on an adapted British educational system, which entailed 6 years of primary education, 4 years of middle school and 7 years of secondary education. Policy makers in Ghana identified several problems with this system, which included prolonged school years and purely academic content of curricula. And so in in 1987, the pre-tertiary education in Ghana was radically reformed. The length for pre-tertiary education was shortened to: 6 years primary, 3 years Junior Secondary School (JSS) and 3 years Senior Secondary School (SSS). In essence, pre-tertiary education was shortened from 17 to 12 years. The direct effect of this reform was that it reduced the cost of pre-tertiary education and made more funds available to expand and improve existing infrastructure so as to partially meet the requirements of the Free and Compulsory Universal Basic Education (FCUBE) for all. Currently, all the WAEC member countries are using this system and it appears similar to the American pre-tertiary education system. Though a lot of effort has gone into the implementation of the new educational system, it has had its fair share of problems. Among others, all of the WAEC member states have been faced with various degrees of poor examination performance in science – as have been determined by WAEC. And the cause may be one of two things, that the educational system is not working well for our students in science or it is lacking the necessary inputs to enable it work efficiently. In any system, a good input usually produces a good output (and vice versa) and so the latter point of lack of necessary inputs may be a large contributor to the poor performance in science of the current educational system. This is not to say that the WAEC member countries including Ghana are not working on the problems. In fact they are, but then they must prioritize Science and Technology to enable it to receive the necessary resources (human, funding and recognition) to thrive.
The quality of science and technological education at the Junior Secondary School (JSS) level is crucial because it is a foundation for further science studies at the Senior Secondary School (SSS) or entry into the labor force. However, many of the teachers who handle this subject are SSS graduates who may not have mastery over the subject. This issue is particularly prominent in the private sector. To make the situation worse, many of these SSS graduate teachers of science may not have majored in science at the SSS. And so, poor science is done/delivered at the JSS level making the students perceive science as a difficult and complicated subject – a perception that can be carried with them for the better part of their school life and influence their decisions in Science and Technology in the future. As our student population grows and Science and Technology evolves, so should be our trained teachers. It is a good effort by the government of Ghana to develop the teacher training certificate programs into diploma programs. However, here it is recommended that the government of Ghana makes plans to strengthen the science discipline in the 38 or so training colleges in Ghana and more importantly encourage more teachers to be trained in science and technical skills so that they can replace some of the SSS teachers. Several more training colleges should also be built for that purpose. The other WAEC member countries can work along similar lines.
In 1995, the government of Ghana established the Science Resource Centers (SRC) project as part of the educational reforms. The SRCs covered one hundred and ten (110) senior secondary schools spread across Ghana. The idea behind this project was to bridge the gap between resourced schools and non-resourced schools in science within a forty kilometer radius. Indeed, this was a bold decision taken by government of Ghana. Assuming that the resource centers had enough funds to buy equipment and materials, the one most important element/factor that will be needed for successful delivery of science education at such places will be the competency, dedication and current knowledge in science and technology of the teaching staff. That is not or cannot be guaranteed and so it would not be out of place if professors at our universities are attached to the SRCs – to assist in the teaching of especially more difficult concepts in theory and lab work to both teachers and students. In fact in the United States, many science College professors are tied to the high schools. They go there to teach and also to oversee what their colleagues at the high schools do. This is an inspiration to both teachers and students alike. In the same manner, SSS science teachers should be attached to JSS schools so that they can offer some help in the teaching of the science subject at that level. This measure will allow for fluidity in Science and Technological education in Ghana and other African countries.
The science syllabi of the old educational system and the new one are not very much different in academic content but the students within the new educational system are much younger than the old system. It will not be productive to essentially stick to the science syllabi of the old system if we want to make progress, because those syllabi do not have aspects that seriously deal with the problems of our country. We should seek to comprehensively redesign the science syllabi and make them more relevant to our economy. The syllabi should be able to cover at least some of the basic problems we face as a nation and creative methods (which will not be limiting) to remedy them. I recommend that about 10 – 40% of the science syllabi (whether integrated science or pure science subjects) are devoted for this purpose and the rest to the core science principles – for the duration of the pre-tertiary education. These percentages should be linked to the level of education such that at the primary school level, 10 -15% of the science syllabi will be devoted to problems and solutions confronting the nation, 15-25% at the JSS and 25-40% at the SSS. Equally important is the fact the syllabi should be directed towards raising curiosity, creativity and entrepreneurship in students. To craft such a syllabi will require extensive brainstorming by competent scientist, policy makers and even business people. We should not assume that the problems of the country can be best tackled at the university. National development in Science and Technology in our present circumstances will require the contribution from all.
Another area which needs serious consideration is the lack of well written textbooks (either from the government or the public) to suit the demands of our science and technological development. Most of the science books on the market are still essentially based on the old educational system. Though I think it is a good and bold step to produce indigenous books for use by our students, the book writers must be assisted. It would not be out of place if the Curricula Research and Development Division (CRDD) of the Ghana Education Service and similar bodies of other WAEC member countries organize workshops for book writers in their respective countries or together so that authors are more informed of what is required of them and that the CRDD have some control of what the public consumes in terms of scientific material. From my standpoint, attending the CRDD workshops should be a pre-condition for writing science books, and with time more stringent measures could be put in place to control quality of science material on the market.
These are a few of the adjustments we could make to the pre-tertiary educational sector in Ghana/Africa to boost Science and Technology development. Please look out for the next article.
By 2050 population growth is expected to translate into a 70 percent increase in global demand for food. Add the estimated 27 percent decline in global productivity expected due to climate change, and it is clear that the demand for food production will become more critical in the coming decades.
Countries that depend on rain-fed agriculture will be especially vulnerable. Crop models for Sub-Saharan Africa have indicated that in 2050, average rice, wheat, and maize yields will decline by up to 14 percent, 22 percent, and 5 percent, respectively.
But there are rays of hope as we go towards 2050. The potential for agriculture in Africa is great. African countries can use their own experiences, indigenous knowledge and traditional methods, as well as the many talents of their people to adopt and adapt the best of what science has to offer in new technologies.
An essential lever for raising agricultural productivity is increasing investments in science and technology. An important lesson of the 1960s “Green Revolution” was that agricultural research could contribute decisively to spurring agricultural growth. Countries that simultaneously adopted the technology and increased their investments in agricultural research have maintained and even accelerated their rate of productivity and growth. New technologies – like biotechnology, conservation tillage, drip irrigation, integrated pest management, and new multiple-cropping practices – have improved the efficiency and productivity of agricultural resources over the last decade. Around the world some 14 million small and resource poor farmers in the developing world have already benefited from biotechnology crops.
In a 2008 survey of the global impact of biotech crops, the global net economic benefits to biotech crop farmers was $9.2 billion dollars, divided roughly equally between developed and developing countries. In South Africa, for example, biotech maize, soybean, and cotton are estimated to have enhanced farm incomes by $383 million dollars. In other areas of the world, the technology has changed the lives of farmers and raised incomes in a matter of years. In India, conservative estimates for small-scale farmers have indicated that the use of biotech cotton has increased yield by 31 percent, decreased insecticide application by 39 percent, and increased profitability by 88 percent, equivalent to $250 U.S. dollars per hectare. With the advent of enhanced tools, such as drought-resistant corn and disease-resistant bananas, those who have paved the way for the technology will reap even further economic benefits.
African researchers are already working on the next generation of biotech crops that will have a wider array of benefits for farmers, like drought tolerance, nitrogen-use efficiency, and salt tolerance to help address shifting environments due to climate change. But second generation biotech crops will go beyond benefits to the farmer. Work is underway in crops, like cassava and rice, to increase their vitamin, mineral, and protein content, benefitting the consumer as well.
So we know what technology can do. The question is what has been keeping it out of the hands of those who could benefit from it? In many cases misinformation has made people fear a process and its products. However, the real obstacle is the lack of functioning regulatory systems that would allow countries to make their own decisions about the safety of these products. Biotechnology-produced crops have been assessed for safety in all regions of the world – from the European Union to Japan to Brazil to Burkina Faso. Not to adopt biotechnology because of unfounded claims after more than 15 years of safe use and proven benefits would be to unnecessarily narrow an African farmer’s agricultural potential. It is one of the tools, which, when paired with the right incentives, can enable Africa’s farmers and businesses to close the productivity gap.
But those incentives must have political will behind them. Technology alone is not the answer. To make use of the potential of biotechnology, science-based regulatory systems must be established. I call upon those who have the ability to do so to put in place such sound policies, based on science, and to take full advantage of what investment in agricultural science and technology can do for African farmers and economies.
Several African countries have already adopted the policies and regulatory frameworks needed to support the responsible and safe use of biotechnology. I applaud their courage and foresight to move forward. With increased political will, strong research support, and biosafety policies and regulations that empower the use of the technology, African countries can revolutionize their agricultural sector. What’s more, they can squarely look those in the eye who maintain that crop technology leads to lost markets, and ask them to explain why the expanding economies of the world are exactly those that are developing and using biotechnology.
To those who fear monopolies and multinational ownership of the food supply, I say promote competition, don’t stifle innovation. It is clear that economic growth will be achieved by those countries that are innovators in agriculture and that take the leap of faith needed to invest in their farmers, which is an investment in their future.
Mr. Fernandez was nominated by President Obama on August 6, 2009, and sworn in as Assistant Secretary on December 1, 2009. He serves as the Assistant Secretary of State for Economic, Energy and Business Affairs. He leads the Bureau that is responsible for overseeing work on international trade and investment policy; international finance, development, and debt policy; economic sanctions and combating terrorist financing; international energy security policy; international telecommunications and transportation policies; and support for U.S. businesses and the private sector overseas. Mr. Fernandez was named one of the “World’s Leading Lawyers” by Chambers Global for his M&A and corporate expertise, an “Expert” in International Financial Law Review’s “Guide to the World’s Leading Project Finance Lawyers”, and one of the “World’s Leading Privatization Lawyers” by Euromoney Publications.
Australian scientists using new image and cell technologies have for the first time caught malaria parasites in the act of invading red blood cells. The researchers, from the Walter and Eliza Hall Institute in Melbourne, Australia, and the University of Technology, Sydney (UTS), achieved this long-held aim using a combination of electron, light and super resolution microscopy, a technology platform new to Australia.
The detailed look at what occurs as the parasite burrows through the walls of red blood cells provides new insights into the molecular and cellular events that drive cell invasion and may pave the way for developing new treatments for malaria. Institute researchers Dr Jake Baum, Mr David Riglar, Dr Dave Richard and colleagues from the institute’s Infection and Immunity division led the research with colleagues from the i3 institute at UTS.
Dr Baum said the real breakthrough for the research team had been the ability to capture high-resolution images of the parasite at each and every stage of invasion, and to do so reliably and repeatedly. Their findings are published in today’s issue of the journal Cell Host & Microbe.
“It is the first time we’ve been able to actually visualise this process in all its molecular glory, combining new advances developed at the institute for isolating viable parasites with innovative imaging technologies,” Dr Baum said.
“Super resolution microscopy has opened up a new realm of understanding into how malaria parasites actually invade the human red blood cell. Whilst we have observed this miniature parasite drive its way into the cell before, the beauty of the new imaging technology is that it provides a quantum leap in the amount of detail we can see, revealing key molecular and cellular events required for each stage of the invasion process.”
The imaging technology, called OMX 3D SIM super resolution microscopy, is a powerful new 3D tool that captures cellular processes unfolding at nanometer scales. The team worked closely with Associate Professor Cynthia Whitchurch and Dr Lynne Turnbull from the i3 institute at UTS to capture these images.
“This is just the beginning of an exciting new era of discoveries enabled by this technology that will lead to a better understanding of how microbes such as malaria, bacteria and viruses cause infectious disease,” Associate Professor Whitchurch said.
Dr Baum said the methodology would be integral to the development of new malaria drugs and vaccines. “If, for example, you wanted to test a particular drug or vaccine, or investigate how a particular human antibody works to protect you from malaria, this imaging approach now gives us a window to see the actual effects that each reagent or antibody has on the precise steps of invasion,” he said.
Malaria is caused by the Plasmodium parasite, which is transmitted by the bite of infected mosquitoes. Each year more than 400 million people contract malaria, and as many as a million, mostly children, die.
“Historically it has been very difficult to both isolate live and viable parasites for infection of red blood cells and to employ imaging technologies sensitive enough to capture snapshots of the invasion process with these parasites, which are only one micron (one millionth of a metre) in diameter,” Dr Baum said.
He said one of the most interesting discoveries the imaging approach revealed was that once the parasite has attached to the red blood cell and formed a tight bond with the cell, a master switch for invasion is initiated and invasion will continue unabated without any further checkpoints.
“The parasite actually inserts its own window into the cell, which it then opens and uses to walk into the cell, which is quite extraordinary,” Dr Baum said. “Visually tracking the invasion of Plasmodium falciparum into a red blood cell is something I’ve been aiming at ever since I began at the Walter and Eliza Hall Institute in 2003; it’s really thrilling to have reached that goal. This technology enables us to look at individual proteins that we always knew were involved in invasion, but we never knew what they did or where they were, and that, we believe, is a real leap for malaria researchers worldwide
This work was supported by the National Health and Medical Research Council, The University of Melbourne, Canadian Institutes of Health, the University of Technology, Sydney, and the Australian Research Council.
This image is a composite showing the behavior of different parts of the malaria parasite as it invades a red blood cell, at nanometer scales. The three components of the malaria parasite are labeled with fluorescent proteins (blue = parasite nucleus, red = secretory organelle, green = tight junction). The red blood cell is superimposed on the image for context. Image 1 (Attachment): The parasite is about to invade the red blood cell (unseen to the right of the picture). The tight junction (green) is like a window that the parasite brings with it and inserts into the red blood cell to gain entry. Image 2 (Invasion): This image is mid-invasion, the first time this step has even been visualized. The parasite "opens" the window it has inserted into the cell, and walks through. The secretory organelle (red) secretes its contents through the tight junction (green) and creates a vacuole which the parasite lives within in the red blood cell. In this image we see the parasite nucleus (blue) moving through the ‘window’ into the cell. Image 3 (Sealing): The parasite has completed invasion and is within a vacuole inside the host red blood cell. The window has been closed again, and will break down at a later stage. The parasite is now enclosed within its vacuole (red), the nucleus (blue) showing the parasite safely inside.
Penny Fannin
fannin@wehi.edu.au
In this series of articles, we shall be identifying problems facing the development of Science and Technology in Ghana and attempt to propound solutions to them.
Science is a branch of knowledge that discovers facts about repeated occurrences (whether in nature or in the laboratory) and formulates theories and laws on them. Technology on the other hand is the utilization of these laws to make devices that enhance our living standards or enable us to do more science. In most cases, Science and Technology go hand- in-hand but a strong scientific base is needed for technological advancement.
The importance of Science and Technology cannot be over emphasized. Science and Technology is one of the key paths for rapid economic development and industrialization of any country. Science and Technology allows for the country’s natural resources to be processed in good quantities before exported as value added good (industrialization and commercialization). Science and Technology brings innovation such as discovery of a drug which treats diseases with unmet medical needs or equipment for performing difficult tasks. These innovations (including the processed raw materials) can be exported for foreign exchange, which in turn improves the standards of living of the people of the country and is good way of transforming developing nations like Ghana into the middle income economy or higher.
But Science and Technology is not a natural resource of any country. This resource can be developed or acquired with determination and commitment from governments and policy implementers. When we obtained independence in 1957, Dr. Kwame Nkrumah announced plans for moving Ghana rapidly into middle income economy – by developing the Science and Technology capability and capacity of Ghana. Subsequently he established several research bodies and built infrastructure to see to the implementation of Science and Technology development in Ghana. But most of the institutions/infrastructure he put in place did not benefit much from his foresight as he was overthrown shortly afterwards. Notwithstanding, subsequent governments of Ghana have made modest additions (over approximately 40 years) to the existing infrastructure and institutions for Science and Technology development but the impact has hardly been felt. This is because we are still faced with problems of the primitive technology era such as:
1. Frequent power outages
2. Dependence on rain-fed agriculture and use of hoes, machetes for farming
3. Lack of capacity to process raw materials including maize, cassava, tomatoes and the like
4. Poor health care
5. Heavy dependence on imported goods including food, second-hand clothing and shoes
6. Many parts of the country are still underdeveloped and live in darkness
7. Lack of creativity among many science graduates
8. Dependence on cement for building, with hardly any alternatives
…….Just to mention a few.
What is surprising is that, the problems confronting science and technology in Ghana especially in the 21st century is not different from many an African country and so the question arises as to what African countries consciously or unconsciously do similarly to slow down the development of science and technology? It may not be possible to know all the facts at least from my standpoint of view, but what many African governments share in common among others is that, their countries:
1. Do not have systematic policy for Science and Technology development
2. Have a very small fraction of their Gross Domestic Product (GDP) set aside for Science and Technology development
3. Are not developing and adapting appropriate technology – ‘approtech’ for their economies
4. Are not sharing information in Science and Technology with other African countries
5. Are not building common science research centers for African development
6. Do not have right caliber and number of human resources to teach science
7. Teach science without the necessary creativity and lab work to back it
8. Have high illiteracy and poverty rates making Science and Technology an abstract discipline
9. Are not attracting their citizens who have been scientifically trained in developed countries
If it is the commitment of the government and people of Ghana to transform the country from low income into the middle income economy in the near future, then it is imperative that we make Science and Technology a major resource for Ghana. Because irrespective of the amount and number of natural resources we have, without Science and Technology we can never truly benefit from such resources. In the next few articles we shall attempt to examine the situation further and look at areas that can help improve and develop Science and Technology in Ghana/Africa.