Fight Against Malaria Compromised by Resistance Spread

Scientists have found new evidence that resistance to the front-line treatments for malaria is increasing.

They have confirmed that resistant strains of the malaria parasite on the border between Thailand and Burma, 500 miles (800km) away from previous sites.

Researchers say that the rise of resistance means the effort to eliminate malaria is “seriously compromised”.

The details have been published in The Lancet medical journal.

For many years now the most effective drugs against malaria have been derived from the Chinese plant, Artemisia annua. It is also known as sweet wormwood.

In 2009 researchers found that the most deadly species of malaria parasites, spread by mosquitoes, were becoming more resistant to these drugs in parts of western Cambodia.

This new data confirms that these Plasmodium falciparum parasites that are infecting patients more than 500 miles away on the border between Thailand and Burma are growing steadily more resistant.

The researchers from the Shoklo Malaria Research Unit measured the time it took the artemisinin drugs to clear parasites from the bloodstreams of more than 3,000 patients. Over the nine years between 2001 and 2010, they found that drugs became less effective and the number of patients showing resistance rose to 20%.

Prof Francois Nosten, who is part of the research team that has carried out the latest work, says the development is very serious.

“It would certainly compromise the idea of eliminating malaria that’s for sure and will probably translate into a resurgence of malaria in many places,” he said.

‘Untreatable malaria’

Another scientist involved with the study is Dr Standwell Nkhoma from the Texas Biomedical Research Institute.

“Spread of drug-resistant malaria parasites within South East Asia and overspill into sub-Saharan Africa, where most malaria deaths occur, would be a public health disaster resulting in millions of deaths.”

The scientists cannot tell if the resistance has moved because mosquitoes carrying the resistant parasites have moved to the Burmese border or if it has arisen spontaneously among the population there. Either way the researchers involved say it raises the spectre of untreatable malaria.

“Either the resistance has moved and it will continue to move and will eventually reach Africa. Or if it has emerged, now that artemisinin is the standard therapy worldwide then it means it could emerge anywhere,” Prof Nosten told the BBC.

“If we were to lose artemisinin then we don’t have any new drugs in the pipeline to replace them. We could be going back 15 years to where cases were very difficult to treat because of the lack of an efficacious drug.”

Artemisinin is rarely used on its own, usually being combined with older drugs to help fight the rise of resistance. These artemisinin based combination therapies are now recommended by the World Health Organization as the first-line treatment and have contributed substantially to the recent decline in malaria cases in many regions.

Prof Nosten says the current spread of resistance could be similar to what happened in the 1970s with chloroquine, a drug that was once a front-line treatment against the disease.

“When chloroquine resistance reached Africa in the middle of the 1970s it translated into a large increase in the number of cases and the number of children who died increased dramatically.”

In a separate paper published in the journal Science researchers have identified a region of the malaria parasite genome that is linked to resistance to artemisinin.

Dr Tim Anderson, from Texas Biomed who led this study, says that while mapping the geographical spread of resistance can be challenging it may be hugely beneficial.

“If we can identify the genetic determinants of artemisinin resistance we should be able to confirm potential cases of resistance more rapidly. This could be critically important for limiting the further spread of resistance.”

According to the World Malaria Report 2011 malaria was responsible for killing an estimated 655,000 people in 2010 – more than one every minute. A majority of these were young children and pregnant women.

The BBC  Science Reporter

Joyce Banda is New President of Malawi

Malawi’s Vice-President Joyce Banda has been sworn in as president following the death of Bingu wa Mutharika.

She becomes southern Africa’s first female head of state after taking the oath before parliament in the Malawian capital, Lilongwe.

Ms Banda, who had been vice-president since 2009, was cheered and applauded before, during and after the ceremony.

Mr Mutharika, 78, went into cardiac arrest on Thursday, although his death was not confirmed until Saturday.

The delay in announcing his death had prompted fears of a power struggle.

There had been speculation that the late president’s inner circle was trying to circumvent Malawi’s constitution to prevent Ms Banda from taking over and instead install his brother, Foreign Minister Peter Mutharika.

Ms Banda had fallen out with Mr Mutharika in 2010 and became one of his fiercest critics. She was expelled from the ruling Democratic People’s Party (DPP) and formed the People’s Party.

She was elected as vice-president in 2009 and Mr Mutharika had failed in his attempts to have her removed from her post.

In taking the oath of office, Ms Banda pledged to “defend and preserve the constitution” and to do right to all manner of people, according to law.

She then asked parliament to stand for two minutes’ silence as a tribute to Mr Mutharika.

Asking Malawians to “focus on mourning our father,” Ms Banda added: “It is with a great sense of humility and honour that I accept the huge responsibility of that the people of Malawi have entrusted me with.”

At present, there are just a handful of MPs in her party but the BBC’s Raphael Tenthani in Blantyre says many more are likely to join now that she is president.

On Friday, Information Minister Patricia Kaliati had said Ms Banda could not take over as head of state because she had gone into opposition. The UK, the US and the EU all called on Malawi to respect its constitution.

Appeal for calm

Shortly after Mr Mutharika’s death was confirmed, Ms Banda addressed journalists, flanked by the heads of the army and police, the attorney general and other officials.

She said funeral arrangements would soon be discussed and that 10 days of national mourning would be held.

She also said preparations were being made to bring Mr Mutharika’s body back from South Africa, where he was taken after his cardiac arrest.

Mr Mutharika governed Malawi for eight years, but was recently accused of mismanaging the economy and becoming increasingly autocratic.

He fell out last year with Britain, the former colonial power, which withdrew its direct aid, accusing the Malawian government of mishandling the economy and of failing to uphold human rights.

Malawi is one of the poorest countries in the world, with an estimated 75% of the population living on less than $1 (60p) a day.

The country has suffered shortages of fuel and foreign currency since the UK and other donors cancelled aid.

The Big Picture

Mr. Isaac Oluyi, Author and motivational speaker

No one can achieve any worthwhile achievement without seeing the picture ahead. What this implies is that the future you cannot picture you cannot capture it. Everything that we see without is a product of the picture within. What kind of future do you picture in your mind? Are you so limited by your current circumstances that you cannot see beyond your reality now? No matter what you are going through at the moment, the good news is that if you can dream it you can actually achieve it.

As a university undergraduate I had only a pair of trousers and two shirts. The pair of trousers was brown in colour and this afforded me the opportunity to wear it for a long period of time without washing! Anytime I washed it I had to tie a wrapper, with supplication to God that it would not rain. Otherwise, it would be a disaster. Besides this, I also could not afford to buy lecture materials. So I resorted to borrowing reading materials from colleagues. I would read these materials with voracious appetite as I had to return them on time. It was really a life of struggle, toiling and anguish. In all of these however, I never for once saw myself as a failure. I forged ahead like a Trojan as I could see clearly the big picture – The big picture of a better tomorrow, when I will become a solution provider, when what I was going through would be used to encourage others in similar situations. It was such a bright and beautiful tomorrow! Continue reading “The Big Picture”

George Clooney Arrested at Sudan Embassy

George Clooney arrested at Sudan

George Clooney has been arrested for civil disobedience during a demonstration outside Sudan’s embassy in Washington DC.

The actor was taking part in a protest to warn of a humanitarian crisis in the volatile border area between Sudan and South Sudan.

His father, Nick, was also detained during the demonstration.

George Clooney is a keen Sudan activist and has made a number of trips to the region.

The Hollywood star, his father and fellow activists were led away in handcuffs after reportedly ignoring repeated police warnings to leave the embassy grounds.

George Clooney gives evidence to US Senate Foreign Relations Committee

Secret Service spokesman George Oglivie told the BBC: “George Clooney was arrested for crossing a police line at the Sudan embassy and he’ll be transported to the Metropolitan police department second district.”

Also arrested, said Mr Oglivie, were Martin Luther King III, son of the civil rights leader; Massachusetts Democratic Congressman Jim McGovern; Virginia Democratic Congressman Jim Moran; and National Association for the Advancement of Colored People President Ben Jealous.

Clooney’s arrest comes a day after he met President Barack Obama at the White House to discuss the Sudan situation.

The actor recently secretly travelled across the border to the Nuba Mountains in Sudan, where his group apparently witnessed a rocket attack.

He told the US Senate Foreign Relations Committee this week that what was happening in the region was “ominously similar” to the violence in Darfur.

The UN estimates that nearly 300,000 people have died and 2.7 million been displaced since the Darfur conflict broke out in 2003

Credit: BBC News

Disaster Stalking Children in Africa’s Drought-Prone Sahel Region, Warns UNICEF

A young mother and with her malnourished child at a screening centre in Gamdji. UN Photo/WFP/Phil Behan

16 March 2012 – The United Nations Children’s Fund (UNICEF) is warning that more than a million children below the age of five in the Sahel are facing a disaster amid the ongoing food crisis in the drought-prone region of Africa.

They are among the some 15 million people estimated to be at risk of food insecurity in countries in the Sahel, including 5.4 million people in Niger, three million in Mali, 1.7 million in Burkina Faso and 3.6 million in Chad, as well as hundreds of thousands in Senegal, the Gambia, and Mauritania, according to UN figures.

UNICEF stated that the dry, ‘lean’ season in the affected countries is imminent, and will be marked by rising numbers of children in feeding centres who will need life-saving treatment.

“A multiple disaster is stalking children in the Sahel,” said the agency’s Regional Director, David Gressly. “Even in a best case scenario we are expecting more than a million children suffering from severe and acute malnutrition to enter feeding centres over the next six months.

“More extreme conditions could see the number rise to around 1.5 million, and funding is still not coming at the rate we need to prepare properly,” he added.

The agency noted that it has so far received $24 million against an emergency appeal of $119 million for 2012.

UN agencies and their partners have been responding to the food crisis in the Sahel, which is the result of poor rainfall and failed harvests. The renewed conflict between Government forces and the Tuareg in northern Mali that has uprooted civilians has also increased demand for emergency assistance not only there, but in neighbouring countries that have received refugees.

“The upsurge of fighting in Mali, as well the acute insecurity in northern Nigeria and elsewhere, are complicating the aid operation,” said Mr. Gressly.

“Without a good emergency response and a sustained effort to reduce risk in the medium to long term, an entire generation faces a future of dependency, poverty and threatened survival.”

Earlier this month, the UN Food and Agriculture Organization (FAO) called for $69.8 million in additional funding to prevent a full-blown food and nutrition crisis from unfolding in the Sahel.

 UN News Center

ICC Finds Congolese Warlord Guilty of Recruiting Child Soldiers

Thomas Lubanga was found guilty of conscripting and enlisting children under the age of 15 and using them to participate in hostilities. Photo: ICC-CPI/E. Daniel
Thomas Lubanga was found guilty of conscripting and enlisting children under the age of 15 and using them to participate in hostilities. Photo: ICC-CPI/E. Daniel

14 March 2012 – The International Criminal Court (ICC) today found Congolese warlord Thomas Lubanga Dyilo guilty of recruiting child soldiers, in a landmark ruling hailed by United Nations officials as an important step in the fight against impunity.

The verdict is the first ever to be issued by the ICC, the first permanent international court set up to prosecute individuals for genocide, crimes against humanity, war crimes and the crime of aggression, since it was set up a decade ago.

The Court’s trial chamber found Mr. Lubanga Dyilo guilty of the war crimes of conscripting and enlisting children under the age of 15 into the Patriotic Forces for the Liberation of Congo, and using them to participate actively in hostilities in Ituri in north-eastern Democratic Republic of the Congo (DRC) from September 2002 to August 2003.

“A common plan was agreed by Mr. Lubanga Dyilo and his co-perpetrators to build an army for the purpose of establishing and maintaining political and military control over Ituri. This resulted in boys and girls under the age of 15 being conscripted and enlisted, and used to participate actively in hostilities,” stated a news release issued by the Court, which is based in The Hague.

The verdict was hailed by senior UN officials as a victory for the protection of children in conflict and a major milestone in the fight against impunity.

“Today, impunity ends for Thomas Lubanga and those who recruit and use children in armed conflict,” said the Secretary-General’s Special Representative for Children and Armed Conflict, Radhika Coomaraswamy. “In this age of global media, today’s verdict will reach warlords and commanders across the world and serve as a strong deterrent,” she added.

The UN Children’s Fund (UNICEF) applauded the decision, which makes Mr. Lubanga Dyilo the first warlord to face international justice for using children as weapons of war.

“This is a pivotal victory for the protection of children in conflict,” said UNICEF Executive Director Anthony Lake, adding that the conviction of Mr. Lubanga Dyilo “sends a clear message to all armed groups that enslave and brutalize children: impunity will not be tolerated.”

Noting that tens of thousands of children are still victims of these grave violations in at least 15 armed conflicts around the world, the agency said it will continue efforts to rescue these children and rehabilitate them.

In a statement issued by his spokesperson, Secretary-General Ban Ki-moon emphasized the need for the international community to continue with its efforts to put an end to impunity. He also urged the Congolese authorities to continue to strengthen their efforts to hold accountable all perpetrators of gross human rights violations.

UN High Commissioner for Human Rights Navi Pillay said the decision is “a great step forward” for international justice. “For many years, and on a daily basis, we have been documenting gross violations of human rights of the sort perpetrated by Lubanga against the people of the Democratic Republic of the Congo,” she said.

“The Lubanga verdict sends a strong signal against impunity for such grave breaches of international law that will reverberate well beyond the DRC.”

Also welcoming the decision was the head of the UN peacekeeping mission in DRC (MONUSCO), who stressed that sends “a powerful message to the individuals responsible for grave human rights violations that they will be held accountable for their actions.”

Roger Meece, who is also the Secretary-General’s Special Representative in DRC, strongly urged national authorities to pursue actively investigations and hold to account all who have committed human rights violations.

UN Goodwill Ambassador and Hollywood actress Angelina Jolie was among those who attended the reading of the verdict, which she said is an important moment for the Court, the DRC and the rule of law.

“Perhaps today’s verdict of guilty provides some measure of comfort for the victims of Mr. Lubanga’s actions,” she said. “Most of all, it sends a strong message against the use of child soldiers.”

A separate sentencing hearing for Mr. Lubanga Dyilo will be held at a date to be announced.

The ICC can try cases involving individuals charged with war crimes committed since July 2002. The DRC is one of seven situations under investigation by the Court, along with Central African Republic (CAR), Côte d’Ivoire, the Darfur region of western Sudan, Libya, Uganda and Kenya.

UN IRIN News

Resume Mistakes to Avoid

MSNBC Contributor

You have about 15 seconds to make an impression with your resume. That’s about the amount of time recruiters and hiring managers say they spend with each job seeker’s resume, given the tidal wave of applicants for open positions these days.

As a result, any glaring mistakes can land your resume in the trash bin.

“The wow factor isn’t as important as being precise,” said Ryan Carfley, President and CEO of recruiting firm MRINetwork Personify. But, he added, “even though hiring managers are inundated, you have to stand out, and the only way to do that is with precise examples of achievements, and do it quickly.”

Here’s a rundown of six resume mistakes you’ll want to avoid:

1. Being too vague
One big resume no-no is not getting to the meat of the matter, notes Pennell Locey, a senior consultant at career management and consulting firm Keystone Associates.

This includes focusing only on job responsibilities in your resume and not including specific accomplishments. You’ll get extra minus points for actually using the phrase “responsibilities included,” said Locey.

“A recruiter once told me that [the] phrase immediately raises suspicion, since it can be used as a dodge when you were supposed to deliver something [and] actually didn’t.”

Locey suggests asking yourself what your major accomplishments were, and what you did that made a difference for your employer.

She offers some alternative phrases, such as “streamlined/ initiated a process,” or “maintained compliance at 100%,” or “participated in a fund-raising campaign that delivered X% over plan,” or perhaps “increased website traffic by X%.”

MRINetwork’s Carfley likes to see dollar signs.

The best way to catch a hiring manager’s attention, he said, is to provide something measurable. Don’t say “led the organization in sales.” Instead, say, “Grew revenues from $500,000 to $1 million,” or “reduced project cycle time by two months, saving the company roughly $200,000.”

2. Ignoring the Cyber Age
Many people still look at resumes the same way they did 20 years ago, but with so much communication taking place online these days you have to make your resume tech savvy, experts say.

“Nowadays, since everything is electronic, and electronic ‘contact’ is the first contact you have with HR, headhunters or a corporation, one of the biggest mistakes a person can make is not to include the right keywords for the position you’re applying for, or want,” said Kiki Weingarten, cofounder of career consulting company Atypical Coaching.

She suggests scanning the ads for industries and positions you’re looking into and find the words that are repeated. Those words are a good bet because you can be sure a hiring manager is looking out for them, Weingarten said.

You don’t want to go cyber crazy, though, and go for cyber gimmicks, added Holly Paul, national recruiting leader for Pricewaterhousecoopers. She advises job applicants not to use “emoticons [smiley faces], text message abbreviations or excessive exclamation points.”

Another faux pas is not thinking of what you name your resume document file. If it’s just called “resume,” rename the file to include your name if possible so that a hiring manager can find it easily.

3. Every job but the kitchen sink
In this economy, there’s a good chance a long-term job seeker has a part-time job (or jobs) under his or her belt just to make ends meet. But that doesn’t mean you should include every burger flipping, or retail-selling job you’ve had. Putting too many of those jobs on your resume, especially if they have nothing to do with the job you want, can hurt your chances of landing a new position.

“Resumes are a summary of the most important data,” said Debra Feldman, a job search expert known as the JobWhiz. “In my opinion, a part-time job just to pay the bills would not fall into that category.

“I think if the skills or accomplishments are relevant, then by all means if there is space and it enhances the content, include these achievements,” she added.

However, if you can connect your experience on the sales floor of a home-improvement store to the job you want, then great. I’ve known many high level executives who felt their time on the retail floor, or working behind a counter, helped them better understand how a company worked.

4. Not being your own cheerleader
One of the biggest resume mistakes is “underselling your role or accomplishments,” said Keystone’s Locey.

Job applicants, she continued, “are often worried about appearing to inflate their experiences, or taking credit for something that others also participated in; they often actually under-represent their accomplishments.”

While you don’t want to lay claim to more than you did, “you do want to claim your accomplishments, and make it clear what you actually did,” Locey explained.

So, she advises taking out terms such as “co-led”, “co-created” or similar phrases used multiple times just to show others worked on the same projects as you. And don’t use “assisted”, “supported” or “participated in,” she added. Say what your role on the team actually involved.

Locey said you should ask yourself the following questions:

  • Did I design and deliver a new project in partnership with line managers? What did I do, what was my role?
  • Was my role on the team to track team milestones and ensure the project was on budget/schedule? “Reflect that in what you write in the resume,” she stressed. “It’s more memorable and brings you to life for the reviewer.”

5. Being “cookie-cutter”
I know it’s a pain to tailor every resume to every new job, but if you really want a gig it may be worth the extra work.

Nick Vaidya, managing partner of The 8020Strategy Group, a consulting firm, is sick of seeing the same old, same old.

“I get exasperated looking at resume after resume that talks about what [an applicant] does, or has done,” Vaidya said. “After a while all of the candidates start looking like white penguins on snow. I want the [person] who understands what I need and tailors his or her resume accordingly. I want the yellow penguin.”

And Vaidya downright hates career objectives on resumes, especially if they are “banal and devoid of all ingenuity, integrity and meaning.”

(The best way to provide these three objectives is to simply read the job description and write a resume directed to that, he said.)

6. Forgetting the basics
“Resume mistakes have become smaller and more important with the level of competition out there,” said Steve Langerud, director of professional opportunities at DePauw University and workplace consultant. That’s why you can’t forget the basics when it comes to resume writing.

As a refresher, Langerud offered a list of the basic resume blunders he hears about most often from hiring managers at companies:

  • Poor spelling.
  • Incorrect address or phone number.
  • Font too small to read.
  • Crazy formatting.

“While simplistic, the most effective resumes lead a reader through the material like a good book or magazine article,” Langerud explained. “Every time you change the format with spaces, new fonts, etc., you focus the reader on the format change and away from the content. Keep it simple.”

And Lynne Sarikas, Director of the MBA Career Center at Northeastern University, has her own list of basic things not to include on your resume:

  • Marital status
  • Number of kids
  • Year of graduation (unless it’s recent)
  • Your GPA (unless it’s over 3.7)
  • Your age, a photo and, above all else, lies.

“So much can be verified easily these days,” she said. “If you stretch the truth or embellish it you can quickly be eliminated from consideration.”